Full Description
This book offers a comprehensive overview of the rapidly evolving field of regenerative medicine, including key breakthroughs in clinical therapies. It is further aimed at facilitating ethical, high-quality research in Sports Medicine and Orthopaedics.
Set apart by its unique structure, it bridges the gap between basic science and practical applications. Divided into three distinct sections, it begins by laying a strong foundation, delving into the biological and molecular underpinnings of regenerative medicine, including stem cells, growth factors, gene editing, tissue engineering, nanotechnology, and bio-manufacturing. The second section takes readers on a journey into the clinical applications of regenerative medicine, offering valuable guidance and insights for practitioners. The third section, dedicated to future trends and bio-materials' applications, sheds new light into the evolving landscape of this field.
By providing a structured, comprehensive, and up-to-date resource, it equips researchers, clinicians, residents and students with the knowledge needed to make a positive impact in this ever-expanding domain. Written in collaboration with ISAKOS, this volume serves as an invaluable tool in advancing readers' understanding and practice in the field.
Contents
PART 1: OVERVIEW 1. Regenerative Medicine: fact or fiction?.- 2. Natural healing: can we improve it?.- 3. MSCs: a new approach.- 4. Evidence-Based Use of Regenerative medicine.- 5. Biological therapies in regenerative sports medicine.- 6. Regulation and regenerative treatments.- 7. Biological Factors in maintaining joint health.- PART 2: BASIC SCIENCE 8. Stem cells: different families.- 9. Growth Factors in regenerative medicine.- 10. Multipotent adult progenitor cells.- 11. Preclinical evidence of MSC-derived exosomes.- 12. Introduction to the concept of secretome in orthopaedics.- 13. Micro-RNA in orthopaedics.- 14. Gene therapy in regenerative medicine.- 15. Aragonite off-the-Shelf Implant for Articular Cartilage in Early OA.- 16. Growth and maturation of articular cartilage.- PART 3: CLINICAL APPLICATION 17. Advances in meniscal tissue engineering. - 18. Orthobiologics in meniscus pathology.- 19. Regenerative Medicine in Tendon pathologies.- 20. New treatments for musculoskeletal diseases.- 21. New approach with Personalized Platelet Rich Plasma.- 22. Essential Considerations in Platelet-Rich Plasma Preparations with Emphasis on Platelet Dosing and Bioformulations. There is No One-Size Fits All Method.- 23. Use of new formulation in Hyaluronic Acid in regenerative medicine.- 24. Regenerative Medicine to Improve Skeletal Muscle Healing After Injury, Disease, & Aging.- 25. Early OA treatment using allogeneic human umbilical cord MSCs.- 26. Meniscus repair using synovial stem cells.- 27. Regenerative Medicine for Osteoarthritis of the Knee Using Cell Sheets..- 28. Adipose-derived cell based products for regenerative medicine.- 29. Orthobiologically augmented scaffolds in cartilage repair.- PART 4: FUTURE TRENDS.- 30. Biophysical stimulation in regenerative medicine.- 31. Biological products and biomaterials for tendon regeneration.- 32. iPS cell-based technology for joint resurfacing.- 33. Nanotechnologies, bio-materials, and scaffolds.34. Scaffold-free tissue engineering in osteochondral restoration.- 35. Biomarkers in regenerative medicine and bio-orthopaedics.
