Full Description
This book covers the clinical usage of JAK inhibitors, which target Janus kinases and have shown promising results in the treatment of various dermatologic conditions, including atopic dermatitis, psoriasis, vitiligo, connective tissue disorders, autoimmune bullous diseases and alopecia areata. It is likely that JAK inhibitors will continue to play an important role in the management of these conditions, with clinical trials ongoing to assess their safety and efficacy in the treatment of other dermatologic disorders, such as vitiligo and hidradenitis suppurativa. However, it is important to note that JAK inhibitors can have potential side effects, including increased risk of infections, anemia and thrombosis. Therefore, careful monitoring of patients receiving JAK inhibitors is necessary to ensure their safety.
Jak Inhibitors in Dermatology represents a treatise on this novel topic and discusses that while JAK inhibitors have shown great promise in the treatment of various dermatologic conditions, further research and monitoring is necessary to fully understand their potential benefits and risks. This book is therefore of great interest for all dermatologists as a first step to understanding this novel treatment.
Contents
History of The Jak/Stat Pathway.- Structures of Jak Inhibitors.- Basic Pharmacology and Pharmacokinetics of Jak-Stat Inhibitors.- Mechanism of Action.- Pan-Jak Inhibitors / Non-Selective Jak Inhibitors.- Selective Jak Inhibitor: Abrocitinib (Jak1-Selective).- Selective Jak Inhibitor: Ritlecitinib.- Selective Jak Inhibitor: Upadacitinib (Jak1-Selective).- Novel Jak Inhibitors.- Dermatological Indications: Atopic Dermatitis.- Dermatological Indications: Alopecia Areata.- Dermatological Indications: Psoriasis.- Dermatological Indications: Vitiligo.- Dermatological Indications: E-Other Dermatological Indications.- Topical Jak Inhibitors.- Safety, Toxicity Profile, and Side Effects.- Jak Inhibitors/Drug Interactions.- Use of Jak Inhibitors in Dermatology Under Special Conditions.- The Future of Jak Inhibitors in Dermatology.- Conclusion.- Index.
