Full Description
This book, now in a revised and updated second edition, provides a comprehensive summary of recent progress in boron neutron capture therapy (BNCT). BNCT is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and to release instantaneously two heavy particles with a path length of one cell diameter or less. This in principle allows for tumor cell-selective high-LET particle radiotherapy. In the past BNCT depended solely on fission reactor-based irradiation facilities, but the appearance of accelerator-based neutron sources placed in hospitals has opened a new chapter for BNCT.
This edition covers all the important aspects of BNCT, including neutron sources, boron chemistry, drugs for BNCT, boron analysis and imaging, dosimetry, and radiation biology. The use of BNCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. BNCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in a language that will be readily understood by all participating disciplines.
Contents
1. Principles of Neutron Capture Therapy.- 2. History of Boron Neutron Capture Therapy.- 3. Fission reactor-based neutron irradiation facilities for BNCT.- 4. Neutron sources: accelerators (principles).- 5. Compact Neutron Generator for BNCT.- 6. Cyclotron-based neutron source, Sumitomo BNCT system, "NeuCure".- 7. The accelerator-based BNCT system at the National Cancer Center Hospital (NCCH), Tokyo, Japan..- 8. iBNCT, a linac-based neutron source for boron neutron capture therapy, developed by the Tsukuba group.- 9. Dedicated solutions: Neutron Therapeutics .- 10. Dedicated solutions: DC tandem accelerator.- 11. Project of Proton Linac based BNCT system (A-BNCT) in Korea.- 12. A new neutron irradiation system - Fukushima SiC.- 13. Neutron capture enhanced fast neutron therapy.- 14. Boron chemistry.- 15. Basic Information on Drug Development and Specific Requirements in the Case of BNCT.- 16. Basics of pharmacokinetics and pharmacodynamics.- 17. Drugs for BNCT: BSH and BPA.- 18. A commercially available BNCT Drug: Steboronine® from Stella Pharma.- 19. Boron Compounds: New Candidates for Boron Carriers in BNCT.- 20. Boron Analysis and Boron Imaging in BNCT.- 21. Proteomic Investigations for BNCT.- 22. Boron Imaging - macroscopic: PET.- 23. Boron Imaging: Localized quantitative detection and imaging of Boron by Magnetic Resonance.- 24. In vivo dose distribution imaging.- 25. Physical Dosimetry and Spectral Characterization of Neutron Sources for Neutron Capture Therapy.- 26. The Clinical Commissioning of Beams for Neutron Capture Therapy.- 27. Commissioning of an accelerator-based BNCT facility for clinical purposes.- 28. Treatment Planning.- 29. Prescribing and reporting in BNCT.- 30. Boron Neutron Capture Therapy (BNCT) Radiobiology.- 31. The Tolerance of BNCT.- 32. BNCT of oral cavity melanoma in dogs.- 33. Latest research on radiobiology studies for the application of BNCT to thyroid cancer.- 34. Clinical trial design and strategies for the implementation of BNCT into clinical practice.- 35. External Beam BNCT for Glioblastoma Multiforme .- 36. BNCT, a Useful Modality to Treat Recurrent Malignant Gliomas.- 37. Boron neutron capture therapy for high-grade meningiomas.- 38. Malignant Melanoma.- 39. Head And Neck Squamous Cell Carcinoma: The Helsinki Clinical Trials.- 40. Clinical results: patients with head and neck squamous cell carcinoma who have no other treatment option.- 41. Clinical results: salivary gland cancer.- 42. BNCT for malignant pleural mesothelioma.- 43. BNCT for multiple or disseminated pleural tumors.- 44. BNCT for multiple liver metastases.- 45. Clinical results: Genital tumor.- 46. Boron Neutron Capture Therapy (BNCT) for soft tissue sarcoma.- 47. Boron Neutron Capture Therapy for Children with Malignant Brain Tumors.- 48. Application of Neutron Capture Therapy for Local Recurrent Breast Cancer .- 49. Boron Neutron Capture Synovectomy.- 50. Clinical BNCT facilities in Japan.- 51. Radiation Protection.- 52. Regulatory aspects and licensing of BNCT facilities.
