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Full Description
This book presents state-of-the-art information on the fundamentals of oral biofilm formation. The reader learns about adhesion and early colonization of polymicrobial communities, the biochemistry and function of the oral biofilm matrix, cooperative interactions, as well as antagonism among microbes within oral biofilms.
The past decade has brought major technological advancements in molecular and microscopy technologies changing our understanding of oral biofilms in health and disease. International experts comprehensively describe key strategies and techniques for studying oral biofilms in vitro, ex vivo and in vivo, including imaging, model systems and omics approaches. In addition, the book provides an up-to-date overview of oral biofilms and associated diseases. Innovative antibiofilm strategies are also addressed. These span from eradication or modulation of oral biofilms as a prevention strategy, and nonantibiotic or antibiotic-supplementing approaches such as quorum sensing inhibition, nanoparticles and pre-and probiotics.
The book is a useful introduction to the field for early career scientists interested in basic and translational research on oral biofilms. It is also an interesting read for advanced scientists and clinicians working in dentistry and oral health research, as it gives them a broader view of the topic beyond their area of specialization.
Contents
Part 1: Fundamentals of Oral Biofilm Formation.- Chapter 1: The Biofilm Microenvironment: Structure & Function.- Chapter 2: Coping with Stress in Bacterial Communities: Heterogeneity of Stress Responses and Methods for Mapping Them.- Chapter 3: The Oral Biofilm Microenvironment.- Chapter 4: Pellicle, Adhesion and Early Colonization.- Chapter 5: The extracellular matrix: A scaffold for microbial community assembly and function.- Chapter 6: Molecular, Cellular and Ecological Aspects of Dental Biofilm Development.- Chapter 7: The oral mucosa-fungi interactome. Part 2: Oral Biofilm-Related Diseases.- Chapter 8: Cariogenic biofilms.- Chapter 9: Endodontic biofilms.- Chapter 10: Microbial Biofilms and Pathobiology of Gingivitis and Periodontitis.- Chapter 11: Subgingival ecology of the periodontal pocket.- Chapter 12: Implant related biofilms.- Part 3: Studying Biofilms in vitro or ex vivo.- Chapter 13: Molecular tools for oral biofilm analyses.- Chapter 14: Single, dual species, synthetic community oral biofilm models: New insight provided by biofilm research on the role of bacteriophage and Candidate Phyla Radiation group, as well as community level dynamics.- Chapter 15: Multispecies oral biofilm models.- Chapter 16: Role of saliva in oral biofilm models.- Chapter 17: Preclinical models and methodologies to study biofilms associated with dental caries.- Chapter 18: Models to study interactions between host and oral biofilms.- Part 4: Clinical Studies on Oral biofilms.- Chapter 19: Cohort, longitudinal and cross-sectional studies (Caries related).- Chapter 20: Cohort, longitudinal and cross-sectional studies (Periodontits related).- Chapter 21: Fundamentals of Omics Applications in the Study of Common Oral Diseases.- Chapter 22: Ecological modulation of oral biofilms: novel approaches to treat and prevent oral diseases.- Chapter 23: Innovative, non-antibiotic-based approaches to oral biofilm-related diseases.- Part 5: Future Perspectives.- Chapter 24: The future of oral biofilms research.
