Full Description
This is a comprehensive, in-depth presentation of pulmonary aspergillosis that takes into consideration recent advances in diagnosis and management. Aspergillus is an opportunistic fungus that is ubiquitous in nature and is unique in the spectrum of illness that it may cause. These may range from fulminant invasive pulmonary aspergillosis (IPA) to chronic pulmonary infection to a hypersensitivity reaction in the form of allergic bronchopulmonary aspergillosis (ABPA).
IPA was primarily associated with severe immunocompromised diseases such as leukemia or bone marrow transplantation and diagnosis and management proved difficult. However, there have been significant advances in the diagnosis with the use of non-invasive biomarkers and in the management with more tolerable and effective antifungal agents. The COVID-19 pandemic has also played a role in making pulmonary aspergillosis much more prevalent with expanding risk factors across populations. This book aims to fill the gap and prepare clinicians to deal with this previously rare disease.
The text is divided into six sections. Expert authors start with the basics of microbiology, immunology, and pathology and then move on to clinical and diagnostic considerations. The text is then divided between IPA, chronic pulmonary aspergillosis, and ABPA and the specific considerations of each are detailed. Finally, chapters cover specific and unique areas that complement the full understanding of this topic.
The wide spectrum of conditions associated with pulmonary aspergillosis, the expanding risk factors and the improvement in the diagnosis and management of these conditions, make this entity relevant to all pulmonologists, intensivists, and infectious disease specialists rather than only those practicing in highly specialized centers.
Contents
Part I: Pulmonary aspergillosis: the basics.- 1. Microbiology of Aspergillus.- 2. Immunology and pathogenesis of pulmonary aspergillosis.- 3. Pathology of pulmonary aspergillosis.- Part II: Pulmonary aspergillosis: clinical aspects.- 4. Spectrum of pulmonary aspergillosis.- 5. Diagnostic studies: role of radiology.- 6. Diagnostic studies: role of bio markers.- 7. The role of bronchoscopy and lung biopsy in the diagnosis and management of pulmonary aspergillosis.- 8. Antifungal agents and their role in the management of pulmonary aspergillosis.- 9. The role of surgery in the management of pulmonary aspergillosis.- Part III: Invasive pulmonary aspergillosis (IPA).- 10. IPA in patients with hematological diseases and hematopoietic stem cell transplantation.- 11. IPA in patients with solid transplantation.- 12. Virus associated pulmonary aspergillosis.- 13. IPA in critically ill patients.- 14. Spectrum of pulmonary aspergillosis in patients with COPD.- 15. IPA in other patient population.- .- Part IV: Chronic pulmonary aspergillosis.- 16. Spectrum of chronic pulmonary aspergillosis.- 17. Management of chronic pulmonary aspergillosis.- Part V: Allergic bronchopulmonary aspergillosis (ABPA).- 18. ABPA and asthma.- 19. ABPA and cystic fibrosis.- 20. Allergic Fungal Rhinosinusitis.- Part VI: Pulmonary aspergillosis: other aspects.- 21. Pulmonary Aspergillosis: The multidisciplinary team approach to diagnosis and management.- 22. Pulmonary aspergillosis: special considerations in the pediatric patient.- 23. Extrapulmonary manifestations of aspergillosis.- 24. Pulmonary aspergillosis: overlap syndrome.- 25. Non-aspergillus pulmonary mold infections.
