Full Description
The study and therapeutic application of macrophages is a rapidly developing field. Tremendous progress has been made in understanding the phenotypes and functions of macrophages in healthy and diseased tissues and organs.
Following the great success of Volume 62: "Macrophages - Origin, Functions and Biointervention" published in this series, this new book now focuses on the role of monocytes and macrophages in development, regeneration and disease. This new volume offers an overview of the latest developments in monocyte and macrophage subtypes and functions across various tissues including adipose tissue, bones, liver, lungs, testes, and the nervous system.
The book also reviews existing and potential therapies targeted towards the macrophages and describes their homeostatic functions. It explores how macrophage cell cycle, metabolism, mitochondrial activity, histone acetylation status, and interaction with the extracellular matrix contribute to changes in macrophage phenotype and function in health and disease. Additionally, it examines the interactions between macrophages and cancer cells, bacteria, helminth parasites, and their role in the colonization and spread of HIV.
For ease of reference, the volume is divided into three sections:
Part I Nonimmunologic and immunologic functions of monocytes/macrophages
Part II Tissue/organ specific functions of macrophages
Part III Macrophage functions and dysfunction in diseases
This book will be of interest to researchers working in the fields of developmental biology, immunology, cancer research, and therapeutic applications. It is written to inform and inspire experts and newcomers to the field of macrophages.
Contents
Part I Nonimmunologic and Immunologic Functions of Monocytes/Macrophages.- Chapter 1 Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance.- Chapter 2 Macrophages and the Extracellular Matrix.- Chapter 3 Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages.- Chapter 4 Macrophage Cell Cycle.- Part II Tissue/Organ Specific Functions of Macrophages.- Chapter 5 Origin and Role of Testicular Macrophages in Testis Development, Steroidogenesis, and Spermatogenesis.- Chapter 6 Adipose Tissue Macrophages.- Chapter 7. Liver Macrophage Diversity in Health and Disease.- Part III Macrophage Functions and Dysfunction in Diseases.- Chapter 8 Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors.- Chapter 9 Macrophage Dysfunction in Respiratory Disease.- Chapter 10 Macrophages in Lung Repair and Fibrosis.- Chapter 11 Macrophage Polarization and Its Impact on Osteoporosis.- Chapter 12 Unlocking Macrophage Secrets: Histone Deacetylases in Chronic Transplant Rejection.- Chapter 13 Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair.- Chapter 14 Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: the Multidimensional Nature of Tuberculosis.- Chapter 15 Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.
