Full Description
This comprehensive reference work presents an up-to-date survey of the current scientific understanding of the metabolic syndrome, as well as an overview of the most significant advances in the field. The book offers a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians, researchers and students. The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on excessive consumption of energy-dense food, sedentary lifestyle, and other behaviors that contribute to the pathogenesis of obesity. However, obesity is a highly complex condition that is influenced by genetic as well as environmental factors. The metabolic syndrome comprises of central obesity, hyperglycemia, hypertension, and dsylipidemia. The incidence of metabolic syndrome is growing worldwide, affecting more than one-third of adults in some countries. The metabolic syndrome increases the risk of developing coronary artery disease and stroke, and it is closely associated with fatty liver, dementia, cancer, sleep apnea, kidney failure, and other diseases. This reference work covers the full range of scientific and clinical aspects of obesity and metabolic syndrome: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, pediatric obesity, and clinical management.
Contents
Part I. Epidemiology.- Overview of metabolic syndrome.- Obesity in the United States.- Obesity in Latin America.- Obesity in Sub-Saharan Africa.- Obesity in Middle East.- Obesity in South Asia.- Obesity in East Asia.- Part II. Genetic Factors.- Evolution of obesity.- Genetics of obesity.- Genetics of type 2 diabetes.- Genetics of lipid disorders.- Genetics of cardiovascular risk in obesity.- Part III. Environmental Factors.- Fetal metabolic programming.- Childhood environment and obesity.- Diet and obesity.- The built environment and obesity.- Community networks and obesity.- Part IV. Pathophysiology.- Principles of energy homeostasis.- Carbohydrate, protein and fat metabolism in obesity.- Brain regulation of feeding and metabolism.- Adipose structure (white, brown, beige).- Adipokines and Metabolism.- Gut hormones and obesity.- Gut microbiome, obesity and metabolic syndrome.- Pancreatic islet adaptation and failure in obesity.- Insulin resistance in obesity.- Linking inflammation, obesity and metabolic syndrome.- Dyslipidemia in obesity.- Myokines and metabolism.- Circadian rhythms and metabolism.- Sleep disruption and obesity.- Intermittent fasting and time restricted eating.- Part V. Diseases Associated with Obesity.- Body composition assessment.- Type 2 diabetes: etiology, epidemiology, pathogenesis, treatment.- Obesity and cardiac disease.- Nonalcoholic fatty liver disease.- Metabolic syndrome, GERD, Barrett's esophagus.- Sarcopenic obesity.- Obstructive sleep apnea and other respiratory diseases in obesity.- Reproductive disorders in obesity.- Obesity, metabolic dysfunction and dementia.- Linking obesity, metabolism and cancer.- Endocrine disorders associated with obesity.- Kidney disease in obesity and metabolic syndrome.- Part VI. Prevention and Treatment.- Diet, exercise and behavior therapy.- Pharmacotherapy of obesity and metabolic syndrome.- Bariatric surgery.- Prevention and treatment of childhood obesity and metabolic syndrome.- Global,national and community obesity prevention programs.
