Cardiac Tissue Engineering (Synthesis Lectures on Tissue Engineering)

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Cardiac Tissue Engineering (Synthesis Lectures on Tissue Engineering)

Cohen, Smadar/ Ruvinov, Emil/ Sapir, Yulia

ウェブストア価格 ¥9,621（本体¥8,747）
Springer International Publishing AG（2011/09発売）
外貨定価 UK£ 34.99
ポイント 87pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 190 p.
言語 ENG
商品コード 9783031014567

Full Description

Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization.

This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing.

Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration

Introduction.- The Heart: Structure, Cardiovascular Diseases, and Regeneration.- Cell Sources for Cardiac Tissue Engineering.- Biomaterials: Polymers, Scaffolds, and Basic Design Criteria.- Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct.- Bioengineering of Cardiac Patches, In Vitro.- Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering.- Vascularization of Cardiac Patches.- Acellular Biomaterials for Cardiac Repair.- Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration.