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Full Description
This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
Contents
Section 1: Overview.- Chapter 1: Introduction and overview.- Section 2: Basics of long noncoding RNA Classifications and functions.- Chapter 2: The Complexity of the Mammalian Transcriptome.- Chapter 3: Towards molecular mechanism in long non-coding RNAs: linking structure and function.- Section 3: Long noncoding RNA and inflammation.- Chapter 4: Long noncoding RNAs in Rheumatology.- Chapter 5: LncRNA and Cardiovascular Disease.- Chapter 6: A role for lncRNAs in regulating inflammatory and autoimmune responses underlying type 1 diabetes.- Section 4: Long noncoding RNAs as Therapeutic targets.- Chapter 7: LncRNA Biomarkers of Inflammation and Cancer.- Chapter 8: Functional Implications of Intergenic GWAS SNPs in Immune Related lncRNAs.- Chapter 9: Long noncoding RNAs as Therapeutic Targets.- Section 5: Challenges and Future Directions.- Chapter 10: Challenges and future directions for LncRNAs and inflammation.
