Full Description
This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue.
All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the "management of drug resistance" has been included.
Contents
1.Introduction to Drugs, Drug Targets and Drug Resistance.- 2.Drugs Resistance in Bacterial Diseases.- 3.Drugs Resistance Against Viral Diseases.- 4.Drug Resistance in Protozoal Infections.- 5.Antifungal Drugs: Mechanism of Action and Resistance.- 6.Drug Resistance in Ear, Nose, and Throat Infections.- 7.Drug Resistance in Skin Diseases.- 8.Drugs Resistance in Lungs Diseases.- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges.- 10.Drug Resistance in Kidney Diseases.- 11.Drugs resistance in Heart Diseases.-12.Drugs Resistance in Liver Disease.- 13.Drug Resistance in Cancer.- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS.- 15.Drug Resistance in Reproductive Diseases.- 16.Drug Resistance in Diabetes.- 17.Drug Resistance in Rheumatological Diseases.- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response.- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization.- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat.- 21.Drugs Resistance Management.
