Full Description
This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research.
This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information.
Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.
Contents
Part 1. Pathological, molecular and immunological background of Cutaneous Malignancies.- Pathology of Melanoma and Skin Carcinomas.- Molecular Landscape Profile of Melanoma.- Molecular Landscape of Skin Carcinomas.- Immunological Features of Melanoma.- Part 2. Targeted Therapies in Skin Cancers.- Dabrafenib and Trametinib.- Vemurafenib and Cobimetinib.- Encorafenib and Binimetinib.- Vismodegib.- Sonidegib.- Part 3. Immunological Strategies in Advanced Melanoma.- Ipilimumab.- Nivolumab.- Pembrolizumab.- Talimogene Leharparepvec.- Part 4. Future of Melanoma Immunotherapy.- Perspectives of Immunotherapy in Advanced Melanoma Combinations and Sequencing.- Part 5. Immunological Therapies in Advanced Skin Carcinomas.- Avelumab.- Cemiplimab.- Perspectives of Immunotherapy in Non-Melanoma Skin Cancers.- Part 6. Mechanism of Resistance to Therapy.- Mechanisms of Resistance to Targeted Therapies in Skin Cancer.- Mechanisms of Resistance to Immunotherapy.- Part 7. Perioperative Therapy of Melanoma.- Neoadjuvant and Adjuvant Therapy in Melanoma.- Part 8. Special Techniques and Populations.- Adoptive Cell Therapy Immunological Therapies in Special Populations: HIV, Hepatitis and Organ Transplantation.- Conclusions.
