Full Description
This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.
Contents
Gene structure, expression, and 5-HT2B receptor signaling.-Serotonin function during embryonic development: the 5-HT2B receptor contribution.- Stem cells to decipher the physiological roles of 5-HT2B receptor signaling.-The serotonergic system in hematopoiesis and hematopoietic disorders.- The 5-HT2B receptor, the immune system and neuroinflammation.-5-HT2B Receptor on Macrophages: What for?.-Bone and 2B Serotonin receptor.-Roles of 5-HT2B receptor in pain.- 5-HT2B receptor, the heart and blood vessels.-5-HT2B receptor in Cardiopulmonary Disease.- Serotonin and cardiac Valves Degeneration in dog.- The discovery of 5-HT2B receptor pharmacology through the understanding of drug- induced valvulopathy.- Serotonin and fibrosis.- 5-HT2B receptors in liver.- Metabolic Regulation: Insulin secretion and action.- Drugs of abuse affecting 5-HT2B receptors.-The Role of 5-HT2B receptor on Aggression and Drugs of Abuse.- Role of the serotonin 2B receptor in the reinforcingeffects of psychostimulants.- Serotonin 2B receptor interactions with dopamine network: implications for therapeutics in schizophrenia.- A Role for the 5-HT2B receptor in the Neurobiology of Schizophrenia.- 5-HT2B receptors and antidepressants.- Serotonin and the 5-HT2B receptor in amyotrophic lateral sclerosis.
