Proteostasis and Disease : From Basic Mechanisms to Clinics (Advances in Experimental Medicine and Biology) / Barrio, Rosa (EDT)/ Sutherland, James D. (EDT)/ Rodriguez, Manuel S. (EDT)

タンパク質恒常性と疾患：基礎から臨床まで<br>Proteostasis and Disease : From Basic Mechanisms to Clinics (Advances in Experimental Medicine and Biology)

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タンパク質恒常性と疾患：基礎から臨床まで
Proteostasis and Disease : From Basic Mechanisms to Clinics (Advances in Experimental Medicine and Biology)

Barrio, Rosa (EDT)/ Sutherland, James D. (EDT)/ Rodriguez, Manuel S. (EDT)

ウェブストア価格 ¥35,183（本体¥31,985）
Springer Nature Switzerland AG（2021/04発売）
外貨定価 US$ 169.99
ポイント 319pt

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製本 Paperback:紙装版/ペーパーバック版／ページ数 348 p.
言語 ENG
商品コード 9783030382681

Full Description

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology.

Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Part I. Cancer.- Ubiquitin-Regulated Cell Proliferation and Cancer.- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer.- The Proteasome System in Health and Disease.- Proteostasis Dysregulation in Pancreatic Cancer.- Divergent Modulation of Proteostasis in Prostate Cancer.- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma.- Part II. Neurodegeneration.- Altered Proteostasis in Neurodegenerative Tauopathies.- The Ubiquitin System in Alzheimer's Disease.- The Interplay Between Proteostasis Systems and Parkinson's Disease.- Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides.- Part III. Infection, Inﬂammation and Developmental Disorders.- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends.- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication.- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System.- TRIME3 Ubiquitin Ligases in Rare Genetic Disorders.- Part IV. Diet.- We Are What We Eat: Ubiquitin-Proteasome System (UPS) Modulation Through Dietary Products.