Full Description
In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely.
This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects - kidney, hormonal pathways systems, brain, muscle, etc - of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded.
Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.
Contents
I Heart Failure and thyroid dysfunction: General Aspects.- 1 Thyroid heart interaction: hystorical perspectives .- 2 Epidemiology of Heart Failure.- 3 Heart Failure, overt and subclinical thyroid dysfunction.- 4 Thyroid, Heart Failure and Cardioprotection .- II Heart and Thyroid in Normal and Failed Heart: Basic Aspect.- 5 Mechanism of Action of TH on the Cardiovascular System.- 6 Novel insights into the machinery controlling the cellular response to TH.- 7 Thyroid Hormone Receptor Signaling .- 8 Thyroid Hormone Deiodinative pathways in the normal and Failing Heart.- 9 3-Iodothyronamine mediated TH Metabolism in the Normal and Failing Heart.- 10 Cardiac Myocyte and Vascular Remodeling in altered and normalized TH metabolism.- 11 Thyroid Hormone and Mithocondrial Function and Protection in Normal and Failing Heart TH-Linked Epigenetic Factors in Heart Failure.- 12 TH-Linked Genetic Expression in Heart Failure.- III Heart Failure and Thyroid in clinics.- 13 Thyroid and CardiovascularRisk.- 14 TH abnormalities and systolic and diastolic function.- 15 Heart Failure Drugs and influences on TH Metabolism.- 16 The complex relationship between TH, Kidney and Heart.- 17 TH, Brain and Heart.- 18 Thyroid, Heart Failure and Neuroendocrine Activation.- 19 Thyroid, Heart Failure, oxidative stress and inflammation.- IV TH Treatment in Cardiac Disorders: Current and new perspectives.- 20 Thyroid hormone modalities of administration vs blood and tissue levels.- 21 TH treatment in patients with cardiac disorders: general aspects.- 22 TH analogs in Heart Failure: from the past to new perspectives.- 23 TH Treatment in AMI.- 23 TH Treatment in HF.- 24 TH Treatment in non-HF cardiac disorders.- 25 New approaches to normalize TH profile in HF
