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Full Description
This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for in vivo imaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the "nano" level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes.
Assembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications;
Explains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications;
Presents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.
Contents
Chapter 1. Optical Properties of Tissues in the Near Infrared: Their Relevance for Optical Bioimaging.- Chapter 2. NIR autofluorescence: molecular origins and emerging clinical applications.- Chapter 3. Surface Modification of Near-Infrared-Emitting Nanoparticles for Biomedical Applications.- Chapter 4. Rare earth doped nanoparticles for advanced in vivo near infrared imaging.- Chapter 5. Recent advances in development of NIR-II fluorescent agents.- Chapter 6. Highlights on NIR Carbon Nanotubes applied to biomedical imaging sensing.- Chapter 7. NIR-Infrared Emitting Carbon Nanomaterials for Biomedical Applications.- Chapter 8. NIR-persistent luminescent nanoparticles for bio-imaging, principle and perspectives.- Chapter 9. NIR-emitting bioprobes for low-autofluorescence imaging techniques.- Chapter 10. Polymer-functionalized NIR-emitting nanoparticles: Applications in cancer theranostics and treatment of bacterial infections.- Chapter 11. Near-Infrared Ag2S Quantum Dots: Synthesis, functionalization and in vivo stem cell tracking applications.- Chapter 12. Non-plasmonic NIR activated photothermal agents.- Chapter 13. NIR-based probes and techniques for brain imaging.
