Full Description
Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for one in every three HIV deaths and over 300,000 in 2017 alone. The HIV epidemic has undermined tuberculosis-control efforts in many countries around the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities.
The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.
Contents
1. Overview of the HIV-associated tuberculosis epidemic.- 2 . Epidemiology of Drug-susceptible, Drug-resistant Tuberculosis and HIV in Africa.- 3. Modelling the HIV-associated TB epidemic and the impact of interventions aimed at epidemic control.- 4. Immune responses to Mycobacterium tuberculosis and the impact of HIV infection.- 5. Clinical Manifestations of HIV-associated tuberculosis in adults.- 6. The tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS).- 7. Diagnosis of HIV-associated tuberculosis.- 8. Recent advances in the treatment of latent tuberculosis infection among adults living with HIV.- 9. Treatment of drug-sensitive tuberculosis in persons with HIV.- 10. Drug-resistant TB and HIV.- 11. Co-treatment of tuberculosis and HIV: pharmacologic considerations.- 12. HIV and TB in children.- 13. Neurological TB in HIV.
