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Full Description
This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
Contents
1. Past, present and future of neuronal models in vitro.- 2. In vitro models of neural disorders.- 3. Neuronal cultures and nanomaterials.- 4. Advances in Human Stem Cell Derived Neuronal Cell Culturing and Analysis.- 5. Large scale, high-resolution microelectrode arrays for interrogation of neurons and networks.- 6. Multi-site intracellular recordings.- 7. From MEAs to MOAs: the next generation of bioelectronic interfaces for neuronal cultures.- 8. Scaling spike detection and sorting for next generation electrophysiology.- 9. Burst detection methods.- 10. Reconstruction of functional connectivity from multi-electrode recordings and calcium imaging.- 11. Open-source tools for processing and analysis of in vitro extracellular neuronal signals.- 12. Screening chemicals for potential neurotoxicity and developmental neurotoxicity using neural networks grown on MEAs.- 13. Long-term activity dynamics of single neurons and networks.-14. Electrical and optical closed-loop systems.
