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Full Description
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
Contents
List of figures
List of abbreviations
About the authors
Preface
Chapter 1: MHC and T cell responses
Abstract:
1.1 Genetic organization of the MHC
1.2 MHC structure
1.3 MHC function
1.4 Peptide binding
Chapter 2: Immunoglobulins and B cell responses
Abstract:
2.1 Types of immunoglobulins
2.2 Immunoglobulin structure
2.3 Immunoglobulin function
2.4 Antigen binding
Chapter 3: Scientific publications and databases
Abstract:
3.1 Bibliographical information
3.2 Searching the literature
3.3 General databases containing information on genes and proteins
3.4 Immunological databases
3.5 Small molecule databases
Chapter 4: Database design
Abstract:
4.1 Fundamentals of database design
4.2 ER diagram
4.3 Normalization and normal forms
Chapter 5: Computational T cell vaccine design
Abstract:
5.1 Sequence-based methods
5.2 Structure-based methods
5.3 Broad-based T cell vaccine design
Chapter 6: Computational B cell vaccine design
Abstract:
6.1 Sequence-based methods
6.2 Structure-based methods
Chapter 7: Infectious disease informatics
Abstract:
7.1 Infectious diseases in history
7.2 Microbial sequence analysis
7.3 Detecting natural selection in molecular evolution
Chapter 8: Vaccine safety and quality assessments
Abstract:
8.1 Assessment of ADME/Tox deficiencies
8.2 Assessment of allergenicity
Chapter 9: Vaccine adjuvant informatics
Abstract:
9.1 Virtual combinatorial library
9.2 Chemical file formats
9.3 Considerations for virtual library design
Index
