Protein Dynamics Using Nmr Relaxation

Mayo, Kevin H./ Daragan, Vladimir A.

Imperial College Press（2023/02発売）

• 製本 Hardcover:ハードカバー版／ページ数 300 p.
• 言語 ENG
• 商品コード 9781860940767
• DDC分類 572.6

Full Description

This volume addresses the use of 13C and 15N NMR spectroscopy to derive information on the internal motions of proteins and peptides in solution. Basic methods of NMR relaxation, along with the general theory of correlation functions and spectral densities, are covered, followed by in-depth analyses and comparisons of various motional models and molecular dynamics simulations used to derive protein dynamics information from NMR relaxation experiments. Motional model equations are expressed in computer program-ready format. The text is intended for graduate and post-graduate students as well as professionals.

Contents

Methods of NMR relaxation; general theory of correlation functions and spectral densities; overall tumbling; model-free approaches for calculation of spectral densities; models of internal rotations; relationships between relaxation parameters; internal rotations in protein backbone; molecular dynamics simulations of protein backbone motions; models of side-chain rotations based on molecular dynamics simulations.