Binding, Transport and Storage of Metal Ions in Biological Cells

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Binding, Transport and Storage of Metal Ions in Biological Cells

Maret, Wolfgang (EDT)/ Wedd, Anthony (EDT)

ウェブストア価格 ¥56,888（本体¥51,717）
Royal Society of Chemistry（2014/07発売）
外貨定価 US$ 273.00
ポイント 517pt

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製本 Hardcover:ハードカバー版／ページ数 938 p.
言語 ENG
商品コード 9781849735995
DDC分類 546.3

Full Description

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects.

This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles).

Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance.

This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Overview;

Sodium: Its Role in Bacterial Metabolism;

Potassium;

Magnesium;

Calcium;

Vanadium;

Chromium;

Molybdenum and Tungsten;

Manganese;

Iron in Eukarya;

Iron Uptake and Homeostasis in Prokaryotic Microorganisms;

Iron-Sulfur Clusters;

Ferritin and its Role in Iron Homeostasis;

Cobalt and Nickel;

Platinum;

Binding, Transport and Storage of Copper in Prokaryotes;

Binding, Transport, and Storage of Copper in Mitochondria;

Binding, Transport and Storage of Copper in Eukaryotes;

Silver;

Gold;

Metallothioneins;

Zinc;

Cadmium;

Mercury;

Antimony and Bismuth;

Actinides in Biological Systems;

Aluminium;

Binding, Transport and Storage of Lead;