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Full Description
The expanding field of nanotechnology is now one of the most promising areas of science. However, because some nanoparticles can have a negative impact on human health and the environment, the design of novel materials must always be accompanied by a comprehensive risk assessment. Until now, the information on the methods available has been fragmented and incomplete. This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques. Topics covered include: benefits versus risks, carbon based nanomaterials, environmental detection and quantitative analysis, chemometric modelling, human exposure assessment, toxicity testing, nano-QSAR, risk assessment strategies, policy and regulatory frameworks.
Contents
Nanomaterials: benefits and risks;
Experimental characterizing structural properties of nanoparticles related to their toxicity;
Structure-property mapping methods;
Modelling properties of nanoparticles based on quantum-mechanical methods;
Ontology;
Empirical determination of nanoparticles' behavior in environmental media;
Computational mass-ballance modeling of environmental transport and fate of engineered nanoparticles;
Pharmacokinetics and biological fate of nanoparticles;
Pharmacokinetic-based modeling;
Modeling kinetics of nanoparticle cellular interaction and transport;
Toxicity and Ecotoxicity testing of engineered nanoparticles - experimental point of view;
In vitro toxicity of nanomaterials;
In vivo testing;
Computational modeling of interactions between nanoparticles and other species;
Comprehensive Environmental Assessment as a Tool for Nanomaterial Risk Assessment;
Predicting oxidative stress;
Nano-QSAR
