- ホーム
- > 洋書
- > 英文書
- > Science / Mathematics
基本説明
This practical and concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved. Aimed at chemists, engineers, materials scientists, biochemists and biomedical experts, as well as undergraduate and postgraduate students. It encourages readers to question conventional methods and move towards the "Benign-by-Design" approach of the future.
Full Description
The environmental and health hazards created by industrial chemicals and consumer products must be minimized. For safer products to be designed, the relationships between structure and toxicity must be understood at the molecular level. Green chemistry combined with free radical research has the potential to offer innovative solutions to such problems.
Some solutions are "greener then others", and many necessitate significant financial investment. New technology will only be adopted if real benefit can be shown and sometimes adaptation of existing methods is the best option. The efficiency of processes must be assessed, not only in terms of the final yield, but also cost, environmental impact and waste toxicity.
This practical and concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved. It discusses the pros and cons of free radical chemistry in aqueous systems for synthetic applications. All transformation steps are covered including initiation, propagation, and termination. Useful background knowledge is combined with examples, including industrial scale processes for pharmaceuticals and fine chemicals.
The book helps chemists to choose appropriate methods for achieving maximum output using a modern, environmentally conscious approach. It shows that, armed with an elementary knowledge of kinetics, an understanding of the mechanistic and technical aspects, and some common sense, it is possible to harness free radicals for use in a broad range of applications.
Streamlining Green Free Radical Chemistry is aimed at chemists, engineers, materials scientists, biochemists and biomedical experts, as well as undergraduate and postgraduate students. It encourages readers to question conventional methods and move towards the "Benign-by-Design" approach of the future. References to further reading are provided at the end of each chapter.
Contents
Chapter 1 Development of Free Radical Green Chemistry and Technology: Journey through Times, Solvents, Causes, Effects and Assessments;
Chapter 2 Classical Synthetic Free Radical Transformations in Alternative Media: Supercritical CO2, Ionic Liquids and Fluorous Media;
Chapter 3 Solvent-Free Carbon-Carbon Bond Formations in Ball Mills and in the Solid State;
Chapter 4 Microwaves in Synthesis: How do Microwaves Promote the Reaction in Conventional and Alternative Media?;
Chapter 5 Asymmetric Free-Radical Reductions Mediated by Chiral Stannanes, Germanes, and Silanes;
Chapter 6 Organic Radical Reductions in Water: Water as a Hydrogen Atom Source;
Chapter 7 Tin-Free Radical Reactions Mediated by Organoboron Compounds;
Chapter 8 Thiols as Efficient Hydrogen Atom Donors in Free Radical Transformations in Aqueous Media;
Chapter 9 Advances in the Use of Phosphorus-centered Radicals in Organic Synthesis in Conventional Flasks: Advantages, Reasons and Applications;
Chapter 10 Metal-based Homogeneous Catalysis and Free Radical Synthesis: Advantages, Developments and Scope;
Chapter 11 Radicals and Transition-metal Catalysis: a Complementary;
Solution to Increase Reactivity and Selectivity in Organic Chemistry;
Chapter 12 Reagent Control in Transition-metal-initiated Radical Reactions;
Chapter 13 Enantioselective Radical Reactions and Organocatalysis;
Chapter 14 The Sunny Side of Chemistry: Green Synthesis by Solar Light;
Chapter 15 Sonochemistry: Ultrasound Application in Radical Synthesis;
Chapter 16 Black-light-initiated Free Radical Reactions for Synthetic;
Applications, Micro-reactors and Modified Nucleoside Synthesis;
Chapter 17 Photo-catalysis and Metal-Oxygen-anion Cluster Decatungstate in Organic Chemistry: a Manifold Concept for Green Chemistry;
Chapter 18 Radical Domino Reactions: Intermolecular Telescopic Reactions;
Chapter 19 Telescopic Reactions and Free Radical Synthesis: Focus on Radical and Radical-Ionic Multicomponent Processes;
Chapter 20 Radical-Radical-Radical Telescopic Reactions: from Rules through Reasons to Applications;
Chapter 21 Applications of Conventional Free Radicals and Advances in Total Synthesis: from the Bench to the Future through the Vinyl Radical;
Chapter 22 Streamlining Organic Free Radical Synthesis through Modern Molecular Technology: from Polymer-supported Synthesis to Microreactors and Beyond;
Chapter 23 Radical Reactions and b-Cyclodextrin as a MolecularFerrari: Is There a Hidden Advantage of Speed, Power and Class? From Fundamental Reactions to Potential Applications;
Chapter 24 Artificial Enzymes and Free Radicals: the Chemist's Perspective;
Chapter 25 Applications of Conventional Free Radicals and Advances in Total Synthesis: from the Bench to Nature through SmI2 Radicals as an Efficient Trigger for Radical Cascades, a Journey from Orsay to the 21st Century;
Chapter 26 Innovative Reactions Mediated by Zirconocene: Advantages and Scope;
Chapter 27 Applications of Conventional Free Radicals and Advances in Total Synthesis: Radical Cascades in Bio-inspired Terpene Synthesis;
Subject Index
