- ホーム
- > 洋書
- > 英文書
- > Science / Mathematics
Full Description
Oligopeptides and oligonucleotides, jointly defined as TIDES, have been neglected in the past as potential drugs due to their short half-life and practical difficulties in the manufacturing processes. The consolidation of iterative synthetic techniques, allowing for design of new chemical entities with better pharmaceutical profiles, has led to renewed interest in these compounds. Large scale manufacturing is therefore now required, and it is important that sustainability and green chemistry are considered from the outset.
As the two classes display many similarities, advances in sustainable approaches can easily be adapted from one class to the other. This book brings together all of the information on green synthesis of oligopeptides, which is well established, and all of the preliminary data on green oligonucleotides synthesis, creating a resource that will help chemists to bridge the gap between these two areas.
Contents
Introduction
Green Metrics for a Sustainable Approach in Iterative Processes
Recent Trends in Peptide Drug Discovery and Development
Sustainable Approaches in Solid-phase Peptide Synthesis (SPPS)
Third Wave for Peptide Synthesis: Liquid-phase Peptide Synthesis (LPPS)
Sustainable Approaches to Chemo-enzymatic Peptide Synthesis
Recombinant and Semisynthesis of Peptides
Oligopeptide Regulatory Affairs and Challenges
Oligonucleotide Synthesis and State-of-the-Art Drug Discovery
Sustainable Approaches in Solid-phase Oligonucleotides Synthesis: Current Status and Future Directions
Sustainable Approaches in Liquid-phase Oligonucleotide Synthesis (LPOS)
Stereopure Oligonucleotides
Impact of Impurities on the Quality and Safety of Oligonucleotides as Drug Substances
Oligonucleotide Regulatory Affairs and Challenges
Greening Chromatographic Purification Processes
