Full Description
Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This two-volume set provides an up-to-date treatise on the ongoing research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the most important representative nerve and blistering agents, whilst also covering other potential chemical warfare agents, these books will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The texts will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.
Contents
Volume 1: Development, historical use and properties of chemical warfare agents;
Toxicology of Vesicants;
Toxicology of organophosphorus nerve agents;
Toxicology and treatment of phosgene induced lung injury;
Human exposures to sulfur mustard;
Long-term effects of the chemical warfare agent sulfur mustard;
Toxicokinetics of sulfur mustard;
Modelling organophosphorus chemical warfare nerve agents: A physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) model of VX;
Allometric modelling of mammalian cyanogen chloride inhalation lethality;
Volume 2: Treatment of nerve agent poisoning;
Nerve agents: Catalytic scavengers as an alternative approach for medical countermeasures;
Nicotinic receptors as targets for nerve agents therapy;
Mustard: Pathophysiology and therapeutic approaches;
Clinical and Laboratory Diagnosis of chemical warfare agent exposure;
Verification of exposure to chemical warfare agents;
The impact of new technologies on the elucidation of chemical warfare agent toxicology;
Chemical defence against fentanyls
