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Full Description
One of the most significant discoveries in the field of immunology and medicine in recent times is the enigmatic realm of exosomes. Exosomes, which range in size from 30 to 150 nm, are specific types of extracellular vesicles that are released by nearly all cells. Over the past decade, there has been a significant increase in the detection and understanding of exosomes and how they can be incorporated into the development of innovative therapeutic applications, as well as their role in diagnostic assessments and pathophysiological mechanisms.
This new volume, Clinical Potential of Exosomes: Diagnostic and Therapeutic Insights, explores the diverse roles and features exhibited by cells based on their origin, delving into the intricate mechanisms that govern exosome biogenesis and cargo loading and shedding light on their roles as molecular couriers. The authors discuss valuable insights that exosomes provide on modified cellular or tissue conditions in diverse disorders, and how their identification in biological fluids holds the possibility for a comprehensive diagnostic assessment involving multiple components. The book looks at how the effective transfer of cellular constituents via exosomes can provide valuable insights for the development of exosome-mediated therapies.
The significant and diverse potential of exosomes and extracellular vesicles in the context of managing and combating various diseases and health are discussed, such as for site-specific drug delivery and vaccine delivery; for cancer management; for the treatment of cardiovascular, neurodegenerative, and infectious diseases, as well as for dermal and ophthalmic ailments; in reproductive medicines; and in regenerative medicines as well as gene therapy and personalized care. A chapter also addresses the regulatory aspects and concerns regarding exosome-based drug delivery.
Covering a wide realm of topics on extracellular vesicles, this book provides an in-depth understanding of the multifunctionality of exosomes that has created novel opportunities for precision medicine, providing individualized strategies for the detection, therapy, and surveillance of many medical conditions. This book will be a valuable reference book for researchers, industry professionals, faculty, and students.
Contents
Foreword by Vasso Apostolopoulos Preface 1. Overview of Extracellular Vesicles 2. Genesis of Extracellular Vesicles: Insight to a Complex Ecosystem 3. Isolation and Purification of Extracellular Vesicles 4. Engineered and Surface Modified Exosomes: Site-Specific Drug Delivery 5. Drug Loading in Exosomes 6. Exosomes and Other Extracellular Vesicles: Process, Design, and Characterization 7. Characterization of Exosome and Other Extracellular Vesicles 8. Exosomes and Other Extracellular Vesicles for Diagnostics 9. Exosomes and Other Extracellular Vesicles for Cancer Management 10. Exosomes and Other Extracellular Vesicles for Cardiovascular Diseases 11. Exosomes and Other Extracellular Vesicles for Neurodegenerative Diseases 12. Exosomes and Other Extracellular Vesicles for Infectious Diseases 13. Exosomes and Other Extracellular Vesicles for Reproductive Medicines 14. Exosomes and Other Extracellular Vesicles for Dermal Ailments 15. Theranostic Applications of Exosomes and Other Extracellular Vesicles 16. Exosomes and Other Extracellular Vesicles-Based Vaccine Delivery 17. Exosomes and Other Extracellular Vesicles in Regenerative Medicines 18. Exosomes and Other Extracellular Vesicles in Gene Therapy and Personalized Care 19. Role of Bioinformatics, AI, and ML for Exosomes and Other Extracellular Vesicle-Based Drug Products 20. Regulatory Aspects and Concerns Regarding Exosome-Based Drug Delivery 21. Exosomes and Other Extracellular Vesicles for Ophthalmic Ailments
