Full Description
Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria.This book offers a wide-ranging look at the latest studies, including:foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiotainfections of the urogenital tract, endothelial barriers, and the nervous systemmajor advances in work with Mycobacterium tuberculosis and M. lepraesubcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAsendosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogensresearch into cell autonomous defense pathways that has led to major insights into immunology and innate immunitythe latest developments in technology, for the next steps in the study of intracellularityAll facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.
Contents
Contributors ixPreface xvAbout the Editors xviiI. Cellular microbiology in the study of tissue and organ infections1. Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria 3Anna Spier, Fabrizia Stavru, and Pascale Cossart2 Shigella Pathogenesis: New Insights through Advanced Methodologies 15Pamela Schnupf and Philippe J. Sansonetti3. The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection 41Annika Hausmann and Wolf-Dietrich Hardt4. New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems 59Alyssa C. Fasciano, Joan Mecsas, and Ralph R. Isberg5. The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections 69Dorian Obino and Guillaume Dumenil6. Reaching the End of the Line: Urinary Tract Infections 83Kevin O. Tamadonfar, Natalie S. Omattage, Caitlin N. Spaulding, and Scott J. Hultgren7. The Intracellular Life Cycle of Brucella spp. 101Jean Celli8. Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1 113Sangeeta Tiwari, Rosalyn Casey, Celia W. Goulding, Suzie Hingley-Wilson, and William R. Jacobs, JR.9. Mycobacterium tuberculosis: Bacterial Fitness within the Host Macrophage 127Lu Huang, Evgeniya V. Nazarova, and David G. Russell10. The Wolbachia Endosymbionts 139Frederic Landmann11. Make It a Sweet Home: Responses of Chlamydia trachomatis to the Challenges of an Intravacuolar Lifestyle 155Sebastien Triboulet and Agathe Subtil12. Salmonella Single-Cell Metabolism and Stress Responses in Complex Host Tissues 167Dirk Bumann13. Manipulation of Host Cell Organelles by Intracellular Pathogens 179Titilayo O. Omotade and Craig R. RoyII. Subcellular microbiology14. The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens 199Marcela de Souza Santos and Kim Orth15. Customizing Host Chromatin: A Bacterial Tale 215Michael Connor, Laurence Arbibe, and Melanie Hamon16. Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System 227Samuel Hess and Anura Rambukkana17. Multifaceted Roles of MicroRNAs in Host-Bacterial Pathogen Interaction 247Carmen Aguilar, Miguel Mano, and Ana Eulalio18. Modulation of Host Cell Metabolism by Chlamydia trachomatis 267Marion Rother, Ana Rita Teixeira da Costa, Rike Zietlow, Thomas F. Meyer, and Thomas RudelIII. Autonomous defense pathways in the cell19. Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World 279Charlotte Odendall and Jonathan C. Kagan20. Recognition of Intracellular Bacteria by Inflammasomes 287Petr BrozIV. New technologies to move cellular microbiology to organs and tissues21. Modeling Infectious Diseases in Mice with a "Humanized" Immune System 301Yan Li and James P. di Santo22. A Cinematic View of Tissue Microbiology in the Live Infected Host 315Agneta Richter-Dahlfors and Keira Melican23. Cellular Imaging of Intracellular Bacterial Pathogens 325Virginie Stevenin and Jost Enninga24. Using a Systems Biology Approach To Study Host-Pathogen Interactions 337Amy Yeung, Christine Hale, Simon Clare, Sophie Palmer, Josefin Bartholdson Scott, Stephen Baker, and Gordon DouganIndex 349
