Full Description
Imaging studies are frequently used to evaluate the success of cancer treatments for a variety of tumor types. In Vivo Imaging of Cancer Therapy addresses a variety of cutting-edge imaging techniques, including their use for best practice, and provides examples of results found in both pre-clinical and clinical studies. This comprehensive text covers the entire spectrum of in vivo imaging for oncology, including current approaches to detailed anatomic measurements, MR and optical spectroscopy, and molecular imaging techniques requiring exogenously administered imaging agents. The challenges and approaches to quantification are also outlined. The authors describe technologies and methods that are currently clinically available, and many that are still in a developmental stage or useful only in animal studies. However, it is important to realize that the majority of imaging devices now offered for sale by the major imaging equipment manufacturers did not exist as recently as 3 or 4 years ago. Thus the pace of technology development is such that techniques described here as laboratory or investigational will likely be in clinical use within a few years. In vivo imaging will continue to have profound effects on how we think about, detect, diagnose, treat and monitor cancer. In Vivo Imaging of Cancer Therapy will aide clinicians at all levels in keeping up with the most cutting-edge techniques.
Contents
Role of Imaging in Cancer Treatment.- Preclinical Models of Tumor Growth and Response.- Anatomical Measure of Tumor Growth with Computed Tomography and Magnetic Resonance Imaging.- Positron Emission Tomography Imaging of Blood Flow and Hypoxia in Tumors.- Magnetic Resonance Measurement of Tumor Perfusion and Vascularity.- Computed Tomography Measurements of Perfusion in Cancer Therapy.- [18F]Fluorodeoxyglucose Positron Emission Tomography Assessment of Response.- Measurement of Tumor Proliferation with Positron Emission Tomography and Treatment Response.- Estrogen-Receptor Imaging and Assessing Response to Hormonal Therapy of Breast Cancer.- Quantitative Approaches to Positron Emission Tomography.- Positron Emission Tomography Measurement of Drug Kinetics.- Imaging Genes for Viral and Adoptive Therapies.- In Vivo Magnetic Resonance Spectroscopy in Clinical Oncology.- Magnetic Resonance Probes for Tumor Imaging.- Fluorescent Imaging of Tumors.- Imaging of Apoptosis.
