Full Description
With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery.
Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.
Contents
Part I. Signaling Mechanisms Initiated by Cell Surface Receptors. G Protein-Coupled Receptors and G Proteins, Alfredo Ulloa-Aguirre and P. Michael Conn. G-Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Communication Networks, Thomas M. Wilkie and Michael White. The Insulin Receptor Kinase: Regulation and Therapeutic Significance, Barry I. Posner. Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor, David J. Waxman and Stuart J. Frank. Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex, Craig Montell. Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis, Chang Y. Chung and Richard A. Firtel. gp130-Related Cytokines, Christoph J. Auernhammer and Shlomo Melmed. Part II. Signaling Mechanisms Mediated by Ion Channels Calcium and Lipids. Ion Channels, Deborah J. Nelson and Harry A. Fozzard. Calcium Ions as Intracellular Messengers: Pathways and Actions, Stanko S. Stojilkovic, Melanija Tomic', Taka-aki Koshmimizu, and Fredrick Van Goor. Calcium and Calmodulin-Mediated Regulatory Mechanisms, Anthony R. Means. Protein Kinase C, Alexandra C. Newton. Nitric Oxide, Randy Krainock and Sean Murphy. Phospholipids, J. H. Exton. Part III. Cyclic AMP, Protein Kinases and Protein Phosphatases. Adenylyl Cyclases, Lutz Birnbaumer. Cyclic Nucleotide Phosphodiesterases, Marco Conti. Cyclic Nucleotide-Dependent Protein Kinases, Sharron H. Francis and Jackie D. Corbin. Protein Serine/Threonine Kinases, Jörn Heierhorst, Richard Pearson, James Horne, Steven Bozinovski, Bostjan Kobe, and Bruce E. Kemp. Protein Serine/Threonine Phosphatases, Shirish Shenolikar. Protein Tyrosine Phosphatases, Cynthia V. Stauffacher and Harry Charbonneau. Part IV. Signaling MechanismsInitiated by Nuclear Receptors. The Mechanism of Action of Steroid Hormone Receptors, Donald P. McDonnell. Orphan Receptors, Deepak S. Lala and Richard A. Heyman. Coactivators and Corepressors, Neil J.McKenna, Zafar Nawaz, Sophia Y. Tsai, and Ming-Jer Tsai. CREB Binding Protein-Coactivator Complexes, Riki Kurokawa and Christopher K. Glass. Part V. Molecular Regulation of Cell Proliferation and Death. Cell Cycle Checkpoints, Sally Kornbluth. Molecular Regulation of Apotosis, Rosemary B. Evans-Storms and John A. Cidlowski. T-Cells and Immunosuppression, Andrew W. Taylor. Part VI. Rational Drug Discovery. Rational Drug Discovery and the Impact of New Advanced Technologies, Jonathan Greer. Index.
