Full Description
An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.
Contents
I: Obesity.- 1 Energy Metabolism and Obesity.- 2 Metabolic Parameters and Energy Expenditure Before and After Weight Loss.- 3 Regulation of Food Intake and Body Weight.- 4 Mechanisms of Insulin Resistance in Obesity.- 5 Effects of Obesity on Lipid Metabolism.- II: Noninsulin-Dependent Diabetes Mellitus.- 6 Genetics of Noninsulin-Dependent Diabetes Mellitus (NIDDM).- 7 Insulin Secretion in Type II Diabetes Mellitus.- 8 Insulin Action and Insulin Resistance in Noninsulin-Dependent Diabetes Mellitus.- 9 Dyslipidemia in Noninsulin-Dependent Diabetes Mellitus.- 10 Exercise and Noninsulin-Dependent Diabetes Mellitus (NIDDM).- 11 Glucose Toxicity and Insulin Resistance in NIDDM.- 12 Energy Metabolism and Sympathetic Activity in Patients with Insulin Resistance.- 13 Effects of NIDDM on Vascular Tone Regulation.- III: Insights Gained from Other Insulin-Resistance Syndromes.- 14 Insulin Resistance in the Polycystic Ovary Syndrome.- 15 Dietary Management of NIDDM.- 16 Hypertension and Insulin Resistance.- 17 Lessons Learned from Clinical and Basic Research Applied to the Study of Patients with Severe Insulin Resistance.- 18 Treatment of Obesity Through Changes in Lifestyle.- 19 Syndrome X: Past, Present, and Future.
