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Full Description
Gene silencing is a general term describing the epigenetic processes of gene regulation. The term gene silencing is generally used to describe the "switching off" of a gene by a mechanism other than genetic modification. This book reviews research in the study of gene silencing including RNA silencing in transgenic plants and mycorrhizal research, gene silencing in the CNS and on the most extensively studied systems to mediate siRNA and shRNA delivery into the brain, siRNA delivery strategies as a therapeutic tool in gene therapy, galectin-3 epigenetics and effective methods for selecting siRNA sequences by using the average silencing probability and a hidden Markov model.
Contents
Preface; Transgene Silencing in PlantsPerspectives; RNA Silencing in the Ectomycorrhizal Fungus Laccaria bicolor; Gene Silencing as a Promising Strategy to Target CNS & Neurological Disorders; Polymeric Nanoparticles as Efficient siRNA Delivery Systems; Application of Negatively Charged Hydroxyproline-Based DNA Mimics for Gene Silencing; Gene Silencing & the Analysis of Immune Response in Model Insects; RNAI in Plants - Recent Developments & Applications in Agriculture; Silencing of Galectin-3 by Promoter Methylation during Prostate Cancer Progression: A Novel Transcriptional Regulation of Galectin-3 Expression; Effective Methods for Selecting siRNA Sequences by Using the Average Silencing Probability & a Hidden Markov Model; Small RNA-Mediated Gene Silencing for Plant Biotechnology; Post Transcriptional Gene Silencing Methods for Functional Characterization of Abiotic Stress Responsive Genes in Plants; Genome-Wide Identification & Analysis of miRNAs Complementary to Upstream Sequences of mRNA Transcription Start Sites; Gene Silencing: Theory, Techniques & Applications; RNA Interference Mediated by Cell-Penetrating Peptides; Asymmetric RNA Duplexes as Next Generation RNAi Inducers; Index.NER(01): GB IE
