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Full Description
The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry.
Contents
Introduction
FGF Ligands
FGF Receptors
Heparan Sulphate Proteoglycans
FGF Signal Transduction
Regulators
Integration with Other Signalling Pathways
Mesoderm Induction
Neural Induction
FGF Signalling and Posterior Neural Patterning
FGF Signalling at the Isthmic Organizer
FGF Signalling at the Anterior Neural Ridge
Morphogenesis
Somitogenesis
FGF and Myogenesis
Limb Development
FGF and Left-Right Asymmetry
Perspectives
References
About the Authors
