Full Description
This volumes features contributions on the latest advances in the chemistry, biology and clinical applications of the thymosins from leading scientists and clinicians working in the field. The use of chemically defined and synthesized molecules, rather than crude or partially purified extracts has enabled scientists working in this field to acquire definitive information on the molecular biology, immunology and potential clinical applications of this important class of BRMs.
Paper in this volume cover a wide range of topics including:
advances in the structure, design, immunology and molecular biology of thymosin alpha 1 (Tα1), prothymosin alpha (ProTα) and thymosin beta 4 (Tβ4).
an exploration of role of the thymosins in cardioprotection, neuroplasticity, stem cells, wound healing, inflammation and angiogenesis
clinical applications of Tα1 and other BRMs
a look at the current status of translational trials with Tβ4 in areas of wound repair, cardiovascular disease, epidermolysis bullosa and eye injuries.
The availability of synthetic thymosins enables both researchers and clinicians to acquire definitive information on the immunology, pharmacology and emerging clinical applications of Tα1 and Tβ4. Clinicians will be particularly interested in the most recent reports of clinical responses and diagnostic applications.
This volume will also be of keen interest to biochemists, pharmacologists, immunologists and other basic scientists interested in acquiring information on the state of the art of the latest purification procedures, the chemical characterization, pharmacokinetics, immunopharmacology, and molecular biology of the thymosins alone or in combination with other BRMs and standard therapies.
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Contents
Thymosin [alpha]1: the regulator of regulators? / Bonifazi Pierluigi [and others] Transcription profile of human lymphocytes following in vitro treatment with thymosin alpha-1 / Claudia Matteucci [and others]
Prothymosin [alpha] as robustness molecule against ischemic stress to brain and retina / Hiroshi Ueda [and others]
Thymosin [beta]4 and its postranslational modifications / E. Hannappel
Repolymerization of actin from actin:thymosin [beta]4 complex induced by diaphanous related formins and gelsolin / Hans Georg Mannherz, Antonina Joanna Mazur, and Brigitte Jockusch
Multifunctionality of the [beta]-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing / Clotilde Husson [and others]
Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin [beta]4 in neoplastic diseases / Jian-Miao Liu [and others]
Thymosin [beta]4 regulates migration of colon cancer cells by a pathway involving interaction with Ku80 / Czeslaw S. Cirniewski [and others]
Progression of ocular sulfur mustard injury: development of a model system / Denise Milhorn [and others]
Animal studies with thymosin [beta]4, a multifunctional tissue repair and regeneration peptide / Deborah Philp and Hynda K. Kleinman
Thymosin [beta]4 and cardiac repair / Santwana Shrivastava [and others]
Thymosin [beta]4 facilitates epicardial neovascularization of the injured adult heart / Nicola Smart [and others]
Thymosin [beta]4: a key factor for protective effects of eEPCs in acute and chronic ischemia / Rabea Hinkel [and others]
Thymosin [beta]4: a candidate for treatment of stroke? / Daniel C. Morris [and others]
Thymosin [beta]4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts / H. Paul Ehrlich and Sprague W. Hazard III
Thymosin [beta]4 in multiple myeloma: friend or foe / Jo Caers [and others]
Thymosin alpha 1: past clinical experience and future promise / Cynthia Tuthill, Israel Rios, and Randy McBeath
Thymosin [alpha] 1 for treatment of hepatitis C virus : promise and proof / Kenneth E. Sherman
Thymalfasin in the treatment of hepatitis B and C / A. Chiancio and M. Rizzetto
Immunological modifications during treatment with thymosin [alpha]1 plus antiviral therapy in chronic hepatitis C / E. Grandini [and others]
Thymosin [alpha]1 to harness immunity to pathogens after haploidentical hematopoietic thransplantation / Katia Perruccio [and others]
Preclinical studies with IRX-2 and thymosin [alpha]1 in combination therapy / Paul H. Naylor and John W. Hadden
Combination strategies for enhancing the efficacy of immunotherapy in cancer patients / Federica Moschella [and others]
Thymosin [beta]4: structure, function, and biological properties supporting current and future clinical applications / David Crockford [and others]
Thymosin [beta]4 and corneal wound healing: visions of the future / Gabriel Sosne [and others]
Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin [beta]4 / Steven P. Dunn [and others]
The effect of thymosin treatment of venous ulcers / G. Guarnera, A DeRosa, and R. Camerini
Inherited epidermolysis bullosa: past, present, and future / Jo-David Fine
A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin [beta]4 in healthy volunteers / Dennis Ruff [and others]
