Full Description
With ten million persons afflicted each year, no one is entirely immune to cancer and its devastating effects on individuals and families. But recent advances in the development of cancer vaccines—either as therapeutic agents or as preventative measures—are hopeful indicators of progress in this field. This volume comprises invited chapters from world-renowned researchers and clinicians that shed light on recent steps forward in immunotherapeutic and preventive approaches for future cancer vaccines. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.
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Contents
Some Scientific and Organizational Challenges in Cancer Immunology 1 The Human Cancer Antigen Mesothelin is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC-205/CD205 Receptor on Dendritic Cells 6
Brain Tumor Immunotherapy with Type-1 Polarizing Strategies 18
Harnessing Human Dendritic Cell Subsets to Design Novel Vaccines 24
Dendritic Cell-based Vaccines for Pancreatic Cancer and Melanoma 33
Combining Conventional Therapies with Intratumoral Injection of Autologous Dendritic Cells and Activated T Cells to Treat Patients with Advanced Cancers 41
Witch Hunt Against Tumor Cells Enhanced by Dendritic Cells 51
Harnessing CD1D-restricted T Cells Toward Antitumor Immunity in Humans 61
Immunity Against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1-Positive Tumors in P53-/- Mice 68 Targets of Protective Tumor Immunity 74
Identification of Immunologic Biomarkers Associated with Clinical Response After Immune-based Therapy for Cancer Harnessing Dendritic Cells to Generate Cancer Vaccines 81
Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells 99
Strategies to Enhance the Therapeutic Activity of Cancer Vaccines: Using Melanoma as a Model 107
Hematopoietic Stem and Progenitor Cells and the Inflammatory Response 118
