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Full Description
The most recent developments in hematopoietic stem cell research are presented in this volume, along with their clinical implications. The field of hematopoietic stem cell biology is rapidly advancing, and new ideas and concepts supported by fascinating new technologies captivated the interest and excitement of the participants of the meeting.
The sharing of new ideas and technologies with other scientists represents an invaluable stimulus, particularly for the young investigators in the field. It is hoped that the spirit of the meeting will be carried forward to the readers of this volume and that its content will stimulate new and fruitful projects in the field of stem cell biology.
The major topics covered are genetic and epigenetic regulation of stem cells, stem cell plasticity, stem cell regulation and self-renewal, and embryonic stem cells as well as malignant stem cell biology.
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Contents
Introduction: Donald Orlic, Katja C. Weisel, Willem E. Fibbe, and Lothar Kanz. .
Part I: Malignant Hematopoiesis:.
1. Acute Myeloid Leukemia Stem Cells: John E. Dick.
2. Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold: Hannes Klump, Bernhard Schiedlmeier, and Christopher Baum.
3. Developmental Impact of Leukemic Fusion Genes on Stem Cell Fate: Tariq Enver, Shinobu Tsuzuki, John Brown, Dengli Hong, Rajeev Gupta, Tony Ford, Minenori-Ishimae Egucchi, Mariko Egucchi, and Mel Greaves.
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Part II: Early Hematopoiesis:.
4. Derivation of the Hematopoietic Stem Cell Compartment from Human Embryonic Stem Cell Lines: Mickie Bhatia.
5. Thrombopoietin Regulates Differentiation of Rhesus Monkey Embryonic Stem Cells to Hematopoietic Cells: Zheng Wang, Julia Skokowa, andri Pramono, Matthias Ballmaier, and Karl Welte.
6. The Vascular Wall as a Source of Stem Cells: Manuela Tavian, Bo Zheng, Estelle Oberlin, Mihaela Crisan, Bin Sun, Johnny Huard, and Bruno Peault.
7. Genetic and Functional Characterization of Isolated Stromal Cell Lines from the Aorta-Gonado-Mesonephros Region: Katja C. Weisel and Malcolm A. S. Moore.
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Part III: Mobilization:.
8. Involvement of Proteases in Cytokine-Induced Hematopoietic Stem Cell Mobilization: Gerjo A. Velders and Willem E. Fibbe.
7. Hematopoietic Stem Cell Transplantation across Major Genetic Barriers: Tolerance Induction by Megadose CD34 Cells and Other Veto Cells: Yair Reisner, Hilit Gur, Shlomit Reich-Zeliger, Massimo F. Martelli, and Esther Bachar-Lustig.
8. The Role of Sphingosine 1-Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells: Gabriele Seitz, andreas M. Boehmler, Lothar Kanz, and Robert Möhle.
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Part IV: Gene Expression in Stem Cells:.
9. Epigenetic Regulation of Normal and Cancer Stem Cells: Michael F. Clarke.
10. Distinct Gene Expression Pattern of Malignant Hematopoietic Stem and Progenitor Cells in Polycythemia Vera: Ulrich Steidl, Thomas Schroeder, Christian Steidl, Guido Kobbe, Thorsten Graef, Simone Bork, Sabrina Pechtel, Slawomir Kliszewski, andrea Kuendgen, Ulrich P. Rohr, Roland Fenk, Michael Schroeder, Detlef Haase, Rainer Haas, and Ralf Kronenwett.
11. Hox Genes: From Leukemia to Hematopoietic Stem Cell Expansion: Carolina Abramovich, Nicolas Pineault, Hideaki Ohta, and R Keith Humphries.
Part V: Plasticity:.
12. Engraftment of Bone Marrow-Derived Epithelial Cells: Diane S. Krause.
13. Lineage Promiscuity and Plasticity in Hematopoietic Development: Koichi Akashi.
14. Stem Cell Biology: A View toward the Future: Ihor R. Lemischka.
Part VI: Regulators:.
15. Thrombopoietin and the Hematopoietic Stem Cell: Kenneth Kaushansky.
16. Role of GATA-1 in Normal and Neoplastic Hemopoiesis: Anna Rita Migliaccio, Rosa Alba Rana, Alessandro M. Vannucchi, and Francesco A. Manzoli.
17. Gene Expression in Stem Cell-Supporting Stromal Cell Lines: Pierre Charbord and Kateri Moore.
18. Effect of Tyrosine Kinase Inhibition Using Imatinib on Normal Lymphohematopoietic Cells: Stefan Balabanov, Silke Appel, Lothar Kanz, Peter Brossart, and Tim H. Brümmendorf.
Part VII: Clonality:.
19. Stem Cell Gene Transfer: Insights into Integration and Hematopoiesis from Primate Genetic Marking Studies: Cynthia E. Dunbar.
20. Clonal Multilineage Differentiation of Murine Common Pluripotent Stem Cells Isolated from Skeletal Muscle and Adipose Stromal Cells: Jamie Case, Tamara L. Horvath, Jonathan C. Howell, Mervin C. Yoder, Keith L. March, and Edward F. Srour.
21. Tracking Hematopoiesis at the Single Cell Level: Timm Schroeder.
22. Lymphoid Potential of Primitive Bone Marrow Progenitors Evaluated In Vitro: Hongfang Wang, L Jeanne Pierce, and Gerald J. Spangrude.
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Part VIII: Self-Renewal:.
23. Role of Telomerase in Hematopoietic Stem Cells: Peter M. Lansdorp.
24. The Stem Cell Continuum: Peter J. Quesenberry, Gerald A. Colvin, Mehrdad Abedi, Gerri Dooner, Mark Dooner, Jason Aliotta, Patrick Keaney, Luguang Luo, Delia Demers, Abigail Peterson, Bethany Foster, and Deborah Greer.
25. Human Adaptive Immune System Rag2-/-c-/- Mice: Laurie Chicha, Roxane Tussiwand, Elisabetta Traggiai, Luca Mazzucchelli, Lucio Bronz, Jean-Claude Piffaretti, Antonio Lanzavecchia, and Markus G. Manz
