- ホーム
- > 洋書
- > 英文書
- > Science / Mathematics
基本説明
With contributions from leading experts from around the world, this volume examines the most current break-throughs as well as the challenges that lie ahead in picornavirus research.
Full Description
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases. Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases. Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsI. Introduction to Picornavirus Biology1. Genome Organization and Encoded Proteins, Ann Palmenberg, David Neubauer, and Tim Skern 2. Overview of Taxonomy, Nick J. Knowles, Tapani Hovi, Andrew M. Q. King, and Glyn Stanway 3. The Making of a Picornavirus Genome, Eckard Wimmer and Aniko V. PaulII. Virion Structure and Cell Entry and Assembly4. Virion Structure, Elizabeth E. Fry and David I. Stuart 5. Receptors, Jeffrey M. Bergelson 6. Cell Entry: a Biochemical and Structural Perspective, Hazel Levy, Mihnea Bostina, David J. Filman, and James M. HogleIII. Genome Replication and Translation7. Genome Replication I: the Players, Janet M. Rozovics and Bert L. Semler 8. Genome Replication II: the Process, Karla Kirkegaard and Bert L. Semler 9. Translation and Protein Processing, Encarna Martinez-Salas and Martin D. RyanIV. Alterations of Host Cell Function10. Interference with Cellular Gene Expression, Jonathan D. Dougherty, Nogi Park, Kurt E. Gustin, and Richard E. Lloyd 11. Remodeling Cellular Membranes, Frank van Kuppeveld, George Belov, and Ellie EhrenfeldV. Evolution and Mechanisms12. Mutation, Quasispecies, and Lethal Mutagenesis, Esteban Domingo, Celia Perales, Ruben Agudo, Armando Arias, Cristina Escarmis, Cristina Ferrer-Orta, and Nuria Verdaguer 13. Biological Implications of Picornavirus Fidelity Mutants, Marco Vignuzzi and Raul Andino 14. Recombination in the Evolution of Picornaviruses, Peter Simmonds 15. Picornaviruses as a Model for Studying the Nature of RNA Recombination, Vadim I. Agol 16. Origin and Evolution of the Picornaviridae Proteome, Alexander E. Gorbalenya and Chris Lauber 17. Codon Biases and Viral Fitness, Albert Bosch, Steffen Mueller, and Rosa M. PintoVI. Immune Response and Persistence18. Innate Immune Responses, Vincent R. Racaniello 19. Adaptive Immune Responses, Christopher C. Kemball, Robert S. Fujinami, and J. Lindsay Whitton 20. Persistent Infections, Florence Colbere-Garapin and Howard L. LiptonVII. Pathogenesis of Disease21. Poliomyelitis, Satoshi Koike and Akio Nomoto 22. Group B Coxsackievirus Diseases, Steven Tracy and Nora M. Chapman 23. Rhinovirus and Respiratory Disease, Marc B. Hershenson 24. Hepatitis A Virus, Zongdi Feng and Stanley M. Lemon 25. Foot-and-Mouth Disease, Marvin J. Grubman, Luis L. Rodriguez, and Teresa de los Santos 26. Theiler's Virus Central Nervous System Infection, Thomas Michiels and Raymond P. RoosVIII. Disease Prevention and Treatment27. Vaccine Strategies, David J. Rowlands and Philip D. Minor 28. The Poliovirus Eradication Initiative, Konstantin Chumakov and Olen Kew 29. Antiviral Drugs, Armando M. De Palma and Johan Neyts
