Full Description
A comprehensive survey of the most recent discoveries in this field.Provides a platform of knowledge that will lead to the development of more effective methods for controlling the spread of RNA viruses or modifying their disease course.Synthesizes recent findings in this fast-moving field while also reviewing accepted knowledge. Focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors and how these cellular alarms signal the innate immune response. Examines the ways in which specific major RNA virus families interact with, activate, and elude these signaling pathways and responses. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsI. Introduction1.Introduction and Overview, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. LemonII. Antiviral Signaling Pathways and Their Contributions to Virus Control and Pathogenesis2.Role of Toll-Like Receptors in the Innate Immune Response to RNA Viruses, Sinead E. Keating and Andrew G. Bowie3. Cytoplasmic Pattern Receptors and Signaling in Viral Infections, Osamu Takeuchi and Shizuo Akira4. Mitochondrial Antiviral Signaling, Vijay G. Bhoj and Zhijian J. Chen5. Interferon Regulatory Factors and the Atypical IKK-Related Kinases TBK1 and IKK[e]: Essential Players in the Innate Immune Response to RNA Virus Infection, Meztli Arguello, Suzanne Paz, and John Hiscott6. Jak-Stat Pathway in Response to Virus Infection, Joan E. Durbin7. Interferons and Antiviral Action, Christine L. White and Ganes C. Sen8. The Nuclear Factor-[k]B Transcription Factor Pathway, Amer A. Beg and Xingyu Wang9. The Nuclear Factor-[k]B Signaling Network: Insights from Systems Approaches, Allan R. Brasier10. Type I Interferon Signaling in Shaping Cellular Innate and Adaptive Immunity to Viral Infection, Christine A. Biron11. Biological Impact of Type I Interferon Induction Pathways beyond Their Antivirus Activity, Bahram Razani, Arash Shahangian, Beichu Guo, and Genhong Cheng12. Human Genetic Factors Involved in Viral Pathogenesis, Lennart Svensson and Elin KindbergIII. Activation and Evasion of Host Antiviral Signaling Pathways by RNA Viruses13. RNA Virus Families: Distinguishing Characteristics, Differences, and Similarities, Peter W. Mason and Frank Scholle14. Rhabdoviruses and Mechanisms of Type I Interferon Antagonism, Krzysztof Brzozka and Karl-Klaus Conzelmann15. Filoviruses, Christopher F. Basler16. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, Antonella Casola, Xiaoyong Bao, Allan R. Brasier, and Roberto P. Garofalo17. Suppression of Innate Immunity by Orthomyxoviruses, Randy A. Albrecht and Adolfo Garcia-Sastre18. Bunyaviruses and Innate Immunity, Friedemann Weber and Richard M. Elliott19. Arenaviruses, Juan C. de la Torre20. Regulation of Innate Immunity by the Flaviviridae, Brenda L. Fredericksen and Michael Gale, Jr.21. Evasion of Innate Host Antiviral Defenses by Picornaviruses, Stanley M. Lemon22. Togaviruses, William B. Klimstra and Kate D. Ryman23. Coronaviruses and Arteriviruses, Krishna Narayanan and Shinji Makino24. Caliciviridae and Astroviridae, Susana Guix and Mary K. Estes25. Innate Immune Responses Elicited by Reovirus and Rotavirus, Barbara Sherry, John T. Patton, and Terence S. DermodyIV. Summary and Perspectives26. Summary and Perspectives, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon
