生後1000日の生物学 The Biology of the First 1,000 Days (Oxidative Stress and Disease)

生後1000日の生物学<br>The Biology of the First 1,000 Days (Oxidative Stress and Disease)

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生後1000日の生物学
The Biology of the First 1,000 Days (Oxidative Stress and Disease)

Karakochuk, Crystal D (EDT)/ Whitfield, Kyly C. (EDT)/ Green, Tim J (EDT)

ウェブストア価格 ¥50,688（本体¥46,080）
CRC Press Inc（2017/09発売）
外貨定価 US$ 250.00
ポイント 460pt

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製本 Hardcover:ハードカバー版／ページ数 494 p.
言語 ENG
商品コード 9781498756792
DDC分類 618.2

Full Description

The first 1,000 days, from conception to two years of age, is a critical period of growth and development. Exposures to dietary, environmental, hormonal, and other stressors during this window have been associated with an increased risk of poor health outcomes, some of which are irreversible. The book addresses this crucial interval of early life across biological disciplines, linking concepts related to all biological fields to outcomes during the first 1,000 days (e.g. fetal growth and pregnancy outcomes) and beyond (e.g. gut microbiome and cardiovascular disease later in life). The strength of this book lies in its cross-disciplinary nature.

FOREWARD. Rational and objective for the book. Understanding the biology of the 1,000 days. INTRODUCTION. Epidemiology of the 1,000 days (problem & magnitude). WHAT IS NORMAL GROWTH? INTERGROWTH. Fetal Growth Standards. WHO Growth Standards. Birth Cohorts. NUTRITION REQUIREMENTS IN THE LIFE STAGES. Preconception. Pregnancy and fetal. Lactation. Infant/Young Child. ENDOCRINOLOGY IN THE REGULATION OF GROWTH. Role of growth factors and hormones in pregnancy and child growth (vitamin D/calcium/vitamin D, calcium, vitamin K). Thyroid function and growth: mechanisms of iodine. ABNORMAL FETAL DEVELOPMENT AND CONGENITAL BIRTH DEFECTS. Neural tube defects: mechanisms of folate. Other congenital defects: Cleft lip/palate, heart defects, gastrointestinal defects, neuroblastoma. ADVERSE PREGNANCY AND BIRTH OUTCOMES. Nutrition and pathophysiology of gestational diabetes & macrosomia. Nutrition and pathophysiology of preeclampsia. Nutrition and gestational hypertension. Pathophysiology of low birthweight/SGA. Preterm infants. PATHOPHYSIOLOGY AND NUTRITION REQUIREMENTS IN CHILD MALNUTRITION. Moderate acute malnutrition. Severe acute malnutrition. Chronic malnutrition. Oedema and other metabolic complications of malnutrition. BODY COMPOSITION. Maternal weight gain and body composition during pregnancy and lactation. Stages of body composition change from infancy to young childhood. THE GUT MICROBIOME. Early life gut microbiome. Impact of different exposures on gut flora and integrity. Effects of early feeding practices on immunological response/allergy. EFFECTS OF EARLY-LIFE NUTRITION ON ADULT HEALTH AND DISEASE. Impact of epigenetic and environmental exposures on fetal, infant, child growth. Fetal origins of obesity, cardiovascular disease and type 2 diabetes. BEFORE AND BEYOND THE 1,000 DAYS. A role for preconception nutrition. Interpregnancy intervals and birth spacing. Child/adolescent growth. EFFECTIVE INTERVENTIONS DURING THE 1,000 DAYS. Summary of the evidence from the Lancet series. Global progress in the SUN movement. FUTURE DIRECTIONS FOR RESEARCH. Summary of authors responses from each chapter.