Full Description
This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques neededto quantify experiments that use nanoparticles in the nervous system.
Contents
Optocapacitance Allows for Photostimulation of Neurons without Requiring Genetic Modification.- Nanoparticle-Assisted Localized Optical Stimulation of Cultured Neurons.- 3. Stimulation of Primary Auditory Neurons Mediated by Near-Infrared Excitation of Gold Nanorods.- Nanoparticle Preparation for Magnetothermal Genetic Stimulation in Cell Culture and in the Brain of Live Rodents.- Genetically Encoded Nanoparticle for Neural Modulation.- Two Applications of Gold Nanostars to Hippocampal Neuronal Cells: Localized Photothermal Ablation and Stimulation of Firing Rate.- Regulating Growth Cone Motility and Axon Growth by Manipulating Trageted Superparamagnetic Nanoparticles.- Assessment of the Effects of a Wireless Neural Stimulation Mediated by Piezoelectric Nanoparticles.- Influence of External Electrical Stimulation on Cellular Uptake of Gold Nanoparticles.- Estimating the Effects of Nanoparticles on Neuronal Field Potentials Based on their Effects on Single Neurons In Vitro.- The Application of In Vivo Extracellular Recording technique to Study the Biological Effects of Nanoparticles in Brain.- Using the Whole Cell Patch Clamp Technique to Study the Effect of Nanoparticles in Hippocampal Neurons.- Comparative Analysis of Neurotoxic Potential of Synthesized, Native and Physiological Nanoparticles.- A Stoichiometrically-Defined Neural Co-Culture Model to Screen Nanoparticles for Neurological Applications.- Long-Term Organ Distribution Kinetics of Microwave Hydrothermally Synthesixed ZrO2: Pr Nanoparticles in the Organism of Adult Mouse.- Gold Nanoparticles as Nucleation Centres for Amyloid Fibrillation.
