Full Description
In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.
Contents
Preface.- Epidemiology and Aetiology of Head and Neck Cancers.- Head and Neck Cancer Prevention.- Cellular and Molecular Pathology of Head and Neck Tumors.- Oncogenomics/Proteomics of Head and Neck Cancers.- Genetics and Epigenetics of Head and Neck Cancer.- Immunology of Head and Neck Cancer.- HPV and EBV in Head and Neck Cancer.- Head and Neck Cancer Staging and Prognosis: Perspectives of the UICC and the AJCC.- Biomarkers in Head and Neck Cancer.- Hypoxia in Head and Neck cancers: Clinical Relevance and Treatment.- Translational Research in Head and Neck Oncology.- Preclinical Models of Head and Neck Squamous Cell Carcinoma.- Morphologic Investigations in Head and Neck Cancer.- Ultrasound Investigations in Head & Neck Cancer Patients.- Functional Imaging.- Sentinel Node Biopsy for Head and Neck Cancer.- Approaches to Supportive Care.- Intensity-Modulated Radiation Therapy for Head and Neck Cancer.- Principles of Systemic Chemotherapy for Squamous Cell Head and Neck Cancer.- Molecular Targeted Therapies in Head and Neck Cancer.- Phase I Study Methodology in Head and Neck Oncology.- Evidence-Based Head and Neck Oncology: Principles and Pitfalls.- Programs of Organ and Function Preservation.- Multidisciplinary Approach of Unresectable Disease.- Laser Endoscopic Treatment.- Multidisciplinary Management of Skull Base and Superstructure Tumors.- Multidisciplinary Management of Oral Cavity and Maxillary Sinus Cancers.- Management of Nasopharyngeal Carcinoma.- Multidisciplinary Management of Oropharynx Carcinomas.-Multidisciplinary Management of Hypopharyngeal Carcinoma.- Cancers of the Larynx: Tis, T1, T2: Evaluation and Management.- Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers.- Principles and New Approaches in Surgical Reconstruction.- Multidisciplinary Treatment of the Neck.- Postoperative Management of High-Risk Resectable Head & Neck Cancer.- Management of Salivary Gland Cancer.- Head and Neck Melanoma.- Cervical Lymph Node Metastasesof Squamous Cell Carcinoma from an Unknown Primary Site.- The Management of Thyroid and Parathyroid Cancers.- Head and Neck Paragangliomas.- Treatment of the Elderly Head and Neck Cancer Patient.- Interstitial Radiation Therapy in Cancer of the Oropharynx and Oral Cavity.- Proton Beam Therapy for Head and Neck Cancer.- Normal Tissue Complications and Protection in Head and Neck Cancer Patients.- Rehabilitation of Heavily Treated Head and Neck Cancer Patients.- Salvage Therapy in Head and Neck Cancer Patients.- Systemic Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck.-Best Supportive Care for Palliative Treatment.- Quality of Life in Head and Neck Cancer Patients.- Quality Assurance of Clinical Trials in the Management of Cancer in the Head and Neck.
