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Full Description
This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).
Contents
Introduction.- Structural Plasticity in Adult Nervous System: A Historic Perspective.- Impact of Injured Tissue on Stem Cell Fate.- Role of Neural Stem and Progenitor Cells in the Adaptation of the Brain to Injury.- Role of Adult Neurogenesis in Seizure-Induced Hippocampal Remodeling and Epilepsy.- Neurogenesis and Gliogenesis in the Postnatal Hypothalamus: a new level of plasticity for the regulation of hypothalamic function?.- Regenerative Potential of NG2 Cells.- Oligodendrocyte Progenitors and Brain Remodeling Following Blood Brain Barrier Rupture.- Genomic Integrity of Embryonic and Neural Stem Cells.- Links Between Injury-Induced Brain Remodeling and Oncogenesis?.
