Full Description
In August of 1991, a second Dartmouth International Workshop on the corpus callosum was convened to share and discuss the progress that had been made over the decade that had passed following the first workshop. A nucleus of basic and clinical scientists came together to discuss their work and the work of others in a field that has been broadened clinically by the addition of many new centers throughout the world that are now performing corpus callosotomy for intractable epilepsy. This text was stimulated by the participants' presentations and associated fertile discussions. It is compiled from the conference and subsequent studies. It reflects, both at the basic and clinical level, an important and expanding field of neural science endeavor. In keeping with the present and rapidly expanding field of outcomes assessment, callosotomy is again evaluated in light of a further decade of surgery and follow-up. Callosotomy continues to be a useful, palliative procedure and the indications for its use have been better established. The basic science section is a supplement to the first edition and elaborates progress in both new data and ideas. The section on experimental epilepsy models adds further support to the clinical rationale for callosotomy. Perhaps of greater importance is the contribution of experimental models to our understanding of the propagation of seizure activity. The section on the neuropsychology of the split brain patient demonstrates the continuing major contributions to the understanding of brain and behavior that pour forth from this cornucopia.
Contents
I. Corpus Callosum Organization and Development.- 1: Corpus Callosum: History.- 2: Development of the Corpus Callosum.- 3: The Organization of Callosal Connections in Primates.- 4: Organization and Development of Interhemispheric Connections of the Prefrontal Cortex in Rhesus Monkey.- 5: Ontogeny of Visual Callosal Projections in Primates.- 6: Experimental Manipulations of the Organization of Interhemispheric Projections.- II. Experimental Epilepsy.- 7: Midline Subcortical Structures for Transhemispheric Ictal and Interictal Transmission.- 8: Forebrain Commissures and Limbic Kindling.- 9: Callosal and Thalamic Transection: Effects on Spontaneous and Pentylenetetrazol-Induced Absence Seizures in Rats.- 10: Role of the Corpus Callosum in the Photosensitive Epilepsy of Baboons.- III. Clinical Epilepsy.- 11: Some Historical Aspects of Callosotomy for Epilepsy.- 12: Corpus Callosum Section: Preoperative Evaluation.- 13: EEG Selection for Corpus Callosotomy.- 14: Seizure Types: Results of Partial and Complete Callosotomy in Adults.- 15: Functional Pathways Underlying Ipsilateral and Contralateral Spread of Temporal Lobe Seizures.- 16: Corpus Callosum Section for Complex Partial Seizures.- 17: The Role of Posterior Callosotomy in Patients with Suboptimal Response to Anterior Callosotomy.- 18: Anterior Callosotomy Added to Frontal Lobectomy in Frontal Lobe Epilepsy.- 19: The Role of Frontal Lobe Resections Combined to Callosal Sections in the Treatment of Secondary Generalized Epilepsies.- 20: Open and Stereotactic Segmental Callosotomy: Effects on Seizure Frequency.- 21: Preoperative Evaluation of Children for Corpus Callosotomy.- 22: Corpus Callosotomy in Children.- 23: Absence of Disconnection Syndrome after Early Callosotomy.- 24: Neurological Effects of Callosotomy.- 25: Callosotomy or Hemispherectomy in the Treatment of Patients with Intractable Seizures and Hemiparesis.- 26: Multiple Subpial Transection: A Physiological Approach to Epilepsy Surgery.- IV. Neuropsychology.- 27: Hemispheric Specialization and Interhemispheric Integration: Insights from Experiments with Commissurotomy Patients.
