Full Description
This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches.
Features:
Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting
Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting
Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation
Describes the most recent, emerging, and innovative technologies of drug delivery
Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies
Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies
Contents
Fundamental Issues. Introduction to Drug Delivery and Targeting Systems. Controlled Drug Release: history and future directions. Pharmacokinetics and Biopharmaceutics. Improving the water-solubility of poorly soluble drugs. An overview of epithelial barriers. Parenteral Routes of Drug Delivery and Targeting. Nanoparticles for targeted drug delivery. Challenges and obstacles to targeted drug delivery. Depot formulations. Non-Parenteral Routes of Drug Delivery and Targeting. Oral drug delivery: targeting in the GI tract. Buccal and sublingual drug delivery. Transdermal drug delivery. Nasal drug delivery. Pulmonary drug delivery. Vaginal drug delivery. Ophthalmic drug delivery. Emerging Technologies. Stimuli-sensitive drug delivery systems. Drug delivery to the CNS. Gene delivery systems. Vaccine delivery. Theranostic nanoagents. Nanotechnology in tissue engineering and regenerative medicine. Other Issues. Rational drug discovery, design and development. Regulatory Safety Concerns. Marketing Perspectives.
