Full Description
Treatment of Cancer, Sixth Edition is a multi-authored work based on a single theme-the optimal treatment of cancer. A comprehensive guide to modern cancer treatment, it supports an integrated approach to patient care including radiotherapy, chemotherapy and surgery. The sixth edition has been completely updated to create a useful, practical guide focused on the management of individual tumour types. The characteristic didactic approach to patient care of previous editions is retained, but now with greater consideration to the options available. This book is a valuable resource for trainees, oncologists, radiation oncologists, surgical oncologists, and haematologists.
Contents
Central Nervous SystemPathologyImagingTreatment of Central Nervous System TumoursIndividual TumoursReferencesOcular and Adnexal TumoursPaediatric TumoursOther Paediatric TumoursAdult TumoursReferencesHead and Neck CancerIntroductionOrganization of Services for PatientsIncidenceHead and Neck Cancer Is a Global ProblemOutcomeAetiologyProblem of Second Primary TumoursStrategies for PreventionGeneral Principles of SurgeryGeneral Principles of RadiotherapyGeneral Principles of Combined Treatment in Head and Neck CarcinomaPalliative CareStaging and PrognosisAssessment of PatientsRole of Prophylactic Treatment to the Neck In Patients with ClinicalNegative Neck and Primary Tumours of the Head and NeckManagement of Potentially Operable Cervical LymphadenopathyTreatment of Inoperable Nodal Disease After Previous RadiotherapyCarcinoma of the LipTumours of the Oral CavityCarcinoma of the OropharynxHypopharynxPosterior Pharyngeal WallLarynxNasopharynxTumours of the Nose and Paranasal SinusesTumours of the EarRare and Unusual Tumours of the Head and NeckReferencesThyroidIntroductionEpidemiologyAetiologyPathogenesisPathology and Natural HistoryDiagnostic EvaluationTumour, Nodes, MetastasesManagement of Differentiated Thyroid CancerRadioactive Iodine Ablation of Residual Thyroid TissueFollow-UpTreatment of Metastatic DiseaseDosimetry of 131I TherapyComplications of Radioiodine TreatmentExternal-Beam Radiotherapy and Systemic TherapiesManagement of Anaplastic CarcinomaManagement of Medullary Thyroid CancerManagement of Thyroid LymphomaFuture ProspectsReferencesEndocrine and Neuroendocrine TumoursApud Concept and ApudomasPituitary TumoursMedullary Thyroid CarcinomaGastro-Entero-Pancreatic Endocrine TumoursCarcinoid TumoursGeneral Oncology Principles for Systemic Management of NetPhaeochromocytomaMultiple Endocrine NeoplasiaParathyroid Adenoma and CarcinomaAdrenocortical TumoursReferencesBibliographyBreast CancerEpidemiology Identification of High-Risk GroupsBreast Cancer ChemopreventionPresentation and InvestigationStagingScreeningMolecular GeneticsPathologySurgery for Early Breast CancerAdjuvant TreatmentLocally Advanced DiseaseLoco-Regional RecurrenceSecondary Breast CancerComplications of Metastatic Breast CancerAcknowledgementsReferencesLung CancerEpidemiology and AetiologyClassificationPrevention and ScreeningDiagnosis and StagingManagement of Non-Small-Cell Lung CancerManagement of Small-Cell Lung CancerPalliative CareReferencesOesophageal CancerIntroductionEpidemiology and Aetiological FactorsClinical ManifestationsManagement of Localized (Operable) Oesophageal CancerManagement of Locally Advanced Oesophageal CancerManagement of Advanced Oesophageal CancerReferencesBibliographyHepatocellular Carcinoma Introduction Incidence Hepatocellular Carcinoma ReferencesPancreas Incidence and Mortality Aetiology Genetics Anatomy Pathology and Staging Symptoms and Signs Natural History InvestigationTreatmentSpecial Considerations in the Management of Pancreatic CancerReferencesBiliary TractTumours of the Bile Duct (Cholangiocarcinoma)Gall Bladder CancerFuture TrendsReferencesGastric CancerIncidenceAetiologyDiagnosisPathologyMolecular PathogenesisStagingTreatmentFuture DirectionsReferencesBladder CancerIntroductionEpidemiologyAetiologyGenetics of Bladder CancerPathologyClinical Presentation and InvestigationManagementManagement of Low-Grade Superficial Non-Muscle-Invasive Bladder Cancer High-Grade Non-Muscle-Invasive Bladder Cancer Radiotherapy and Systemic Treatments for Superficial DiseaseManagement of Invasive Bladder CancerAdjuvant ChemotherapySurgical TreatmentRadiotherapy in the Management of Muscle-Invasive Bladder CancerManagement of Advanced DiseaseBibliography ReferencesProstate CancerIntroductionEpidemiology and AetiologyPrevention and ScreeningPathogenesisPathology and StagingClinical FeaturesDiagnosis and StagingPrinciples of ManagementManagement of Organ-Confined DiseaseManagement of Locally Advanced DiseaseManagement of Recurrent Disease After Radical Local TherapyManagement of Metastatic DiseaseConcluding RemarksReferencesColorectal CancerIntroductionIncidence and CauseDiagnosis and the Multidisciplinary TeamPathology of Colorectal TumoursMolecular Pathogenesis of Colorectal CarcinomaPathology of Invasive Colorectal CancersTreatmentFollow-Up After Initial TreatmentSummary and Future DevelopmentsNational Health Service GuidelinesConclusionsReferencesBibliographyAnusAnatomyPathologyEpidemiology and Risk FactorsPresentationDiagnostic Work-Up and StagingManagementLymph-Node MetastasesPrognostic Factors and OutcomeExtra-Pelvic MetastasesRadiation Therapy AloneSurgeryNon-Squamous Cell CancersPeri-Anal CancerPatients With Human Immunodeficiency Virus InfectionReferencesGerm-Cell Cancer of the Testis and Related NeoplasmsIntroductionBackground Diagnosis and StagingAssessment and Staging of DiseaseSerum MarkersStage 1 Disease and Risk of RelapseTreatmentMetastatic DiseaseComplications of TreatmentReferencesRenal Cell CancerIntroduction and EpidemiologyClassification of Renal TumoursInherited Syndromes and the Molecular Biology of Renal Cell CarcinomaRisk FactorsClinical FeaturesClinical Evaluation and StagingLocalized DiseaseDisease RelapseMetastatic Disease - Surgical ManagementMetastatic Disease - Prognostic FactorsMetastatic Disease - Non Surgical ManagementTreatment Options in Non-Clear Cell HistologySequencing of Treatments: First-Line, Second-Line and BeyondConclusionReferencesOvary and Fallopian TubesEpithelial Tumours of the OvaryLow Malignant Potential Tumours of the OvaryNon-Epithelial Tumours of the OvaryReferencesEndometrial Cancer Pathogenesis Histopathology Pathologic Features Affecting Prognosis Investigation Staging and Tumour Classification Treatment Follow-Up References Bibliography Cervix Incidence and Causes Pathology Prevention and Treatment of Pre-Invasive Disease Cervical Screening Clinical Features of Invasive Carcinoma of the Cervix Investigations for Invasive Disease Staging and Prognostic Factors Treatment Complications of Treatment New Developments Conclusions Acknowledgements ReferencesCarcinoma of the Vagina and Vulva Carcinoma of Vagina Carcinoma of the VulvaReferencesGestational Trophoblastic Neoplasia IntroductionGenetics and PathologyEpidemiology and Aetiological Factors Human Chorionic Gonadotrophin Clinical Features Management and Investigations Summary References BibliographyNon-Melanoma Skin Cancer Introduction Aetiology Familial Skin Cancer Syndromes Xeroderma Pigmentosum Pre-Malignant Conditions Actinic Keratosis and Bowen's Disease Basal Cell Carcinoma Squamous Cell Carcinoma Primary Cutaneous Lymphoma Primary Cutaneous T-Cell Lymphoma Primary Cutaneous B-Cell Lymphoma Other Non-Melanoma Skin Cancers Merkel Cell Carcinoma Langerhans Cell Histiocytosis ReferencesMalignant Melanoma Introduction Epidemiology Aetiology Prevention Tumour Biology Diagnosis Pathology Staging and Prognosis Treatment of Primary Melanoma Loco-Regional Recurrent DiseaseDistant Metastatic Disease Targeted Therapies NRAS Mutated Melanoma Kit Mutated Melanoma Targeted Agents in Uveal Melanoma Systemic Therapies Conclusions ReferencesPrimary Bone Tumours Introduction Incidence and Aetiology General Principles of Management Osteosarcoma Ewing Sarcoma Chondrosarcoma Other Primary Bone Tumours Key References ReferencesSoft Tissue Sarcomas Introduction Aetiology Clinical Evaluation Pathology Staging Management of the Extremity, Trunk, or Head and Neck Primary TumourAdjuvant ChemotherapyFunctional OutcomeTreatment of Local RecurrenceRadiotherapy AloneTreatment of Unresectable or Locally Advanced Soft Tissue Sarcoma Management of the Retroperitoneal Primary Lesion Treatment of Metastatic Soft Tissue Sarcoma Management of Gastrointestinal Stromal Tumours Desmoid Tumours ReferencesLeukaemias Introduction Acute Leukaemias Chronic Leukaemias Acknowledgements References Hodgkin Lymphoma Introduction Diagnosis, Staging and Choice of Treatment First-Line Treatment Treatment of Relapsed Hodgkin Lymphoma Special Considerations New Drugs Acknowledgements Key References ReferencesNon-Hodgkin Lymphoma Epidemiology and Risk Factors, Classification, Staging and Molecular Pathogenesis of Non-Hodgkin Lymphoma Aggressive Non-Hodgkin Lymphoma Primary Mediastinal (Thymic) Large B-Cell Lymphoma Central Nervous System Lymphoma and Prophylactic Central Nervous System Chemotherapy Burkitt Lymphoma Mantle Cell Lymphoma Human Immunodeficiency Virus - Associated Lymphoma Peripheral T-Cell Lymphoma Indolent Non-Hodgkin Lymphoma Marginal Zone Lymphoma Future Developments Key Reference ReferencesMultiple Myeloma Introduction Incidence and Aetiology Pathogenesis and Biology Clinical Features and Complications Investigation, Diagnosis and Staging Prognostic Factors and Staging Course of the Disease When to Start Treatment and Criteria For Response General Aspects of Care Myeloma Therapy Radiotherapy High-Dose Therapy and Stem-Cell Transplantation Maintenance and Consolidation Therapy Bisphosphonates Refractory and Relapsed Disease New Approaches to Treatment Other Related Conditions ReferencesPaediatric Oncology General Introduction Epidemiology of Childhood Cancer Childhood Leukaemia Hodgkin's Lymphoma Nodular Lymphocyte Predominant Hodgkin Lymphoma Non-Hodgkin Lymphoma Burkitt's Lymphoma and Diffuse Large B-Cell Lymphoma Precursor T- and B-Cell Lymphoblastic Lymphoma Anaplastic Large Cell Lymphoma Liver Cancers Neuroblastoma Ewing's Family Tumours Treatment Osteosarcoma Renal Tumours Staging Investigations Malignant Germ Cell Tumours Non-Central Nervous System Tumours Rhabdomyosarcoma Central Nervous System Tumours Primitive Neuroectodermal Tumours Astrocytic Tumours Central Nervous System Germ Cell Tumours Primitive Neuroectodermal Tumours Astrocytic Tumours Central Nervous System Germ Cell Tumours Atypical Teratoid Rhabdoid Tumours Central Nervous System Tumours In Infants and Very Young Children Organ Toxicity Psychological Aspects of Childhood Cancer Management of Acute Neurological Complications ReferencesAIDS-Related Malignancy Introduction Aids-Defining Malignancies Non-Aids - Defining Malignancies Other Non-Aids - Defining Malignancies Castleman's Disease References Clinical Cancer Genetics Introduction Cancer Pre-Disposition Genes Research Approaches For the Identification of Cancer Pre-Disposition Genes Cancer Risks Associated With Cancer Pre-Disposition Genes Management of A Known Or Suspected Cancer Pre-Disposition Gene Mutation Carrier Summary Key References ReferencesLifestyle Factors in Cancer Survivorship Adiposity and Weight Gain Diet and Dietary Supplements Foods Supplements Carcinogen Avoidance Smoking Alcohol Physical Activity After Cancer Evidence that Physical Activity Improves Survival and Reduces Relapse Rates Summary References
