Taurine 4 : Taurine and Excitable Tissues (Advances in Experimental Medicine and Biology)

Della Corte, Laura (EDT)/ Huxtable, Ryan J. (EDT)/ Sgaragli, Giampietro (EDT)

Springer-Verlag New York Inc.（2013/03発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 652 p.
• 言語 ENG
• 商品コード 9781475773422
• DDC分類 572

Full Description

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Contents

Keynote Presentation.- Appreciations.- Plenary Presentations.- Basic Aspects and Peripheral Actions of Taurine.- Metabolic and Nutritional Aspects.- Taurine in the CNS.- Taurine Analogues and Metals: Health Care Aspects.- Taurine and Vision.- Taurine and Cell Homeostatic Mechanisms.- Clinical Aspects.