Full Description
Stuart Handwerger, MD and a distinguished panel of clinicians and experts review the most significant recent developments in molecular and cellular biology, powerful advances that have produced new diagnostic methods and improved treatments for many pediatric endocrine diseases. Topics range from the growth hormone/prolactin/placental lactogen gene family and their regulation of growth, to steroid hormones, sexual development, and mineral corticoid action. Additional chapters examine the pathophysiology of insulin-dependent diabetes mellitus, the molecular genetics of thyroid cancer, the molecular basis of hypophosphatemic rickets, and inherited diabetes insipidus. Molecular and Cellular Pediatric Endocrinology offers today's clinicians and researchers not only the latest findings on endocrine diseases in their pediatric manifestations, but also highly practical insights into today's cutting-edge diagnostics, treatment strategies, and powerful new therapeutics.
Contents
1 Molecular Basis of Disorders of Sexual Differentiation.- 2 Insulin-Like Growth Factor Control of Growth: Insights from Targeted Disruption of Murine Genesand from Human Disease.- 3 Molecular Defects in the Growth Hormone Axis.- 4 The Molecular Basis of Hypophosphatemic Rickets.- 5 The Roles of Growth Hormone, Prolactin, and Placental Lactogen in Human Fetal Development: Critical Analysis of Molecular, Cellular, and Clinical Investigations.- 6 Growth Hormone Releasing Hormone: Biological and Molecular Aspects.- 7 The Glomerular Physiology of Diabetic Nephropathy.- 8 P450c17— The Qualitative Regulator of Steroidogenesis.- 9 The Molecular Basis of Inherited Diabetes Insipidus.- 10 Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor.- 11 Estrogen Biology: Evolving New Concepts.- 12 Molecular Genetics of Thyroid Cancer: Evidence That Inactivationof Tumor Suppressor Genes Occurs at Late Stages of TumorProgression.- 13 The Molecular Basis of Mineralocorticoid Action.- 14 Molecular Aspects of Pituitary Development.- 15 Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy.- 16 Molecular and Cellular Basis of Immune-Mediated (Type 1) Diabetes.- 17 Molecular Basis of Multiple Pituitary Hormone Deficiency.
