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Full Description
The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
Contents
1 Biophysical Methods in Virus Research.- 1. Introduction.- 2. Viscosity.- 3. Diffusion.- 4. Centrifugation.- 5. Sedimentation Equilibrium.- 6. Chromatography.- 7. Electrophoresis.- 8. Osmotic Pressure.- 9. Light Scatter.- 10. Theory of Electron Microscopy.- 11. References.- 2 Use of Electron Microscopy in Virology.- 1. Introduction.- 2. Specimen Methods.- 3. Survey of Results.- 4. Conclusion.- 5. References.- 3 Structural Studies of Viruses with X-Rays and Neutrons.- 1. Introduction.- 2. Physical Basis of X-Ray and Neutron Scattering.- 3. Structures of Spherical Viruses.- 4. Helicoidal Viruses.- 5. Conclusions.- 6. References.- 4 Serological Methods in the Identification and Characterization of Viruses.- 1. Introduction.- 2. Reagents.- 3. Neutralization.- 4. Agglutination.- 5. Precipitation.- 6. Tests with Labeled Antibodies.- 7. Complement Fixation.- 8. Immunoelectron Microscopy.- 9. Applications of Serological Methods.- 10. References.- 5 Chemical Modification of Viruses.- 1. Introduction.- 2. Reagents Used for Virus Modification.- 3. Modifications for Specific Purposes.- 4. Conclusions.- 5. References.- 6 Photobiology of RNA Viruses.- 1. Introduction.- 2. Plant Viruses.- 3. RNA Bacteriophages.- 4. Animal Viruses.- 5. Conclusion.- 6. References.- 7 The Photobiology of the DNA Viruses ?,T4, and ?X174.- 1. Introduction.- 2. ? Phage.- 3. UV Effects on Bacteriophage T4 (T2 and T6).- 4. UV Effects on ?X174.- 5. Conclusion.- 6. References.