Full Description
This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of experts in the field of chiral chromatography and to hear about the latest developments. Hopefully. in future symposia on chiral separations at the University of Surrey.
Contents
The Biological Importance of Chirality and Methods Available to Determine Enantiomers.- Drug Analysis Using High-Performance Liquid Chromatographic (HPLC) Chiral Stationary Phases: Where to Begin and Which to Use.- Systematic Studies of Chiral Recognition Mechanisms.- Separation of Enantiomers of Oxyphenonium Bromide by High-Performance Liquid Chromatography.- The Use of Pirkle High-Performance Liquid Chromatography Phases in the Resolution of Enantiomers of Polycyclic Aromatic Hydrocarbon Metabolites.- The Role of Solvents and Steric Factors in the Resolution of ?-Blocker Drugs on Chiral Urea Phases.- Complexation of Dansyl Amino Acid Enantiomers by ?-Cyclodextrin Studied by High-Performance Liquid Chromatography and Fluorescence Measurements.- Analytical and Preparative Chiral Resolution of Some Aminoalcohols by Ion-Pair High-Performance Liquid Chromatography.- Simultaneous Enantioselective Determination of Underivatized ?-Blocking Agents and their Metabolites in Biological Samples by Chiral Ion-Pairing High-Performance Liquid Chromatography.- Chiral Gas and High-Performance Liquid Chromatographic Analysis of Enantiomers of Fungicides and Plant Growth Regulators: Application in Fungal, Plant and Soil Metabolism Studies.- Recent Developments in Enantiomer Separation by Complexation Gas Chromatography.- Use of Various Commercially Available Chiral Stationary Phases in Supercritical Fluid Chromatography.- Strategies for Optimising Chiral Separations in Drug Analysis.- Further Use of Computer Aided Chemistry to Predict Chiral Separations in Liquid Chromatography: Selecting the Most Appropriate Derivative.- An Optical Rotation Detector for High-Performance Liquid Chromatography.- Prospects for Chiral Thin-Layer Chromatography.- Appendix 1 — Chiral ChromatographyLiterature 1987-1988.- Appendix 2 — Some Manufacturers and Suppliers of Chiral Columns.- Appendix 3 — Abstracts.- Author Index.- Compound Index.
