Full Description
This book examines evolving paradigms in antigen presentation, dendritic cell biology, innate response and immunosuppressive mechanisms and strategies for manipulation of the immune system to treat neuroblastoma, leukemia, melanoma, lung cancer and more.
Contents
Contents Part I Immune Activation, Suppression and Manipulation of the Immune Antitumor Response Myeloid-Derived Suppressor Cells in Cancer...Christos E. Kyriakopoulos, Alberto J. Montero, and Claudia Marcela Diaz-Montero The Role of B Cells in Shaping the Antitumor Immune Response...Yu Zhang, Taylor H. Schreiber, and Joseph D. Rosenblatt Heat-Shock Protein-Based Cancer Immunotherapy...Taylor H. Schreiber Activation of NK Cell Responses and Immunotherapy of Cancer...George J. Weiner Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay...Eli Gilboa Employing T Cell Homeostasis as an Antitumor Strategy...Shawn M. Jensen, Christopher C. Paustain, and Bernard A. Fox Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor...Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus, and Zelig Eshhar Part II Evolving Clinical Immunotherapeutic Strategies Immunotherapy in Renal Cell Carcinoma...Jennifer Cudris and Jaime R. Merchan Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies...Aaron P. Rapoport and Nadia Ijaz Bifunctional Antibodies: Preclinical and Clinical Applications...Casey W. Shuptrine and Louis M. Weiner Clinical Development of Antibody-Fusion Proteins for Cancer Therapy...Kory L. Alderson, Amy K. Erbe, Margaret Boyden, and Paul M. Sondel Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy...Lazaros J. Lekakis and Krishna V. Komanduri The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities...Paolo Serafini and Donald T. Weed T Cell Co-regulatory Signals and Their Role in Cancer Therapy...Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, and Joseph D. Rosenblatt Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints...Theresa L. Whiteside Index
