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Full Description
The Second International Workshop on Human Leukocyte Differentia- tion Antigens was held in Boston, September 17-20, 1984. More than 350 people interested in leukocyte differentiation agreed to exchange reagents and participate in this joint venture. All in all, in excess of 400 antibodies directed against surface structures on T lymphocytes, B lymphocytes, and myeloid-hematopoietic stem cells were characterized. Because of the enormous quantity of serologic, biochemical, and functional data, Leuko- cyte Typing II has been divided into three volumes. These books represent the written results of workshop participants. They should be helpful to both researchers and clinicians involved in scientific endeavors dealing with these broad fields of immunobiology. To those who delve into the various sections of the volumes, it will become evident that the work speaks for itself. I am deeply indebted to the section editors, Barton F. Haynes, Volume 1, Human T Lymphocytes, Lee M. Nadler, Volume 2, Human B Lympho- cytes, and Irwin D.
Bernstein, Volume 3, Human Myeloid and Hemato- poietic Cells for their major contributions in planning, executing, and summarizing the workshop, as well as council members John Hansen, Alain Bernard, Laurence Boumsell, Walter Knapp, Andrew McMichael, Cesar Milstein, and Stuart F. Schlossman. I would also like to thank the National Institutes of Health, World Health Organization, and Interna- tional Union of Immunological Societies for making this meeting possible.
Contents
I. Introduction.- 1. Summary of T Cell Studies Performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens.- II. Functional Studies.- 2. Binding and Functional Analysis of the Workshop T Cell Specific Set of Monoclonal Antibodies.- 3. Functional Studies Performed with the Second International Workshop T Cell Panel of Monoclonal Antibodies.- 4. The Epitopic Dissection of the CD2 Defined Molecule: Relationship of the Second Workshop Antibodies in Terms of Reactivities with Leukocytes, Rosette Blocking Properties, Induction of Positive Modulation of the Molecule, and Triggering T Cell Activation.- 5. Monoclonal Antibodies as Probes to Define Critical Surface Structures Involved in T Cell Activation.- 6. The Development of Monoclonal Antibodies against Human Immunoregulatory T Cell Subsets: The Isolation of Human Suppressor Inducer T Cell Subset.- 7. Lectin Activation Induces T4, T8 Coexpression on Peripheral Blood T Cells.- 8. Analysis of the Ontogeny and Function of Human Helper T Cell Subpopulations.- 9. Effects of Workshop Monoclonal Antibodies on the Cytolytic Activity of Alloreactive CD4-Positive T Cell Clones.- 10. Effects of the Workshop Anti-T Cell Monoclonal Antibodies on Lymphocyte Proliferative and Cytotoxic Functions.- 11. T Cell Activation by CD3 Antibodies.- 12. Studies of T Cell Proliferation Induced by Monoclonal Antibodies of the Second International Workshop.- 13. Phorbol Ester Induces Changes in the Pattern of Cell Surface Molecules Involved in CTL-Target Cell Interaction.- 14. Analysis of the Monocyte-T Cell Interaction Required for Induction of T Cell Proliferation by Anti-T3 Antibodies.- 15. Evaluation of the T Cell Workshop Monoclonal Antibodies in In Vitro Lymphocyte Proliferation Assays.- 16. The Influence of the Workshop Monoclonal Antibodies on CML, AgTR, PLT, ADCC, and NK Cell Activity. Functional Studies with Workshop Antibodies.- 17. The Influence of Anti-T Cell Monoclonal Antibodies on Calcium Mobilization: Investigation of Workshop Antibodies.- 18. T Cell-Dependent Immunoglobulin Synthesis in the Human System. Studies with T Cell-Specific Monoclonal Antibodies.- 19. Monoclonal Antibodies Recognizing the T3/Leu4 T Cell Differentiation Antigen Induce Suppressor Cells.- 20. Modulation of T Cell Functions by Monoclonal "Pan T Cell" Antibodies Not Directed against the T Cell Receptor Complex.- 21. Determinant Heterogeneity of CD5, CD8, and CD4 Antigen Molecules As Defined by Monoclonal Antibodies.- III. Biochemical Studies.- 22. Immunochemical Analysis of the T Cell-Specific Antigens.- 23. Epitopic Groups of CD1 Molecules.- 24. Comparison of the CD7 (3A1) Group of T Cell Workshop Antibodies.- IV. Phenotypic Characterization of T Cell Leukemias and Lymphomas.- 25. Study on Human T Leukemia-Lymphoma Cell Lines by the Second International Workshop Monoclonal Antibodies of the T Cell Protocol.- 26. Expression of T Cell-Related Antigens on Cells from the Myelo-Monocytic Lineage.- 27. Phenotype of Hodgkin Cells. Expression of the Tac-Antigen and Other Determinants.- 28. The Diversity of T Cell Activation Antigens. Serological Analysis Including Their Expression on Non-T Acute Lymphoblastic Leukemia Cells and B Cell Lines Derived from Adult T Cell Leukemia Patients.- 29. Expression Profiles of T Cell Associated Antigens on Adult T Cell Leukemia Cells: Results of a Workshop Study.- V. Phylogenetic Studies Using Anti-T Cell Antibodies.- 30. The Phylogeny of T Cell Antigens.- 31. Conserved T Lymphocyte-Specific Antigens in Primates.- VI. Study of Anti-T CellAntibodies on Frozen Tissue Sections of Human Tissue.- 32. Ontogeny of Human T Cell Antigens.- 33. Cross-reactivity of Anti-lymphocyte Monoclonal Antibodies on Human Skin Components.- VII. Study of Antibodies Reactive with Antigens of Activated T Cells.- 34. Flow Cytometric Analysis of the Antigens Expressed by Peripheral Blood Lymphocytes Stimulated by Phytohemagglutinin Using the Workshop T Cell Panel and Selected B and M Cell Panel Monoclonal Antibodies.- 35. Regulation of Activation and Proliferation in T Cells.- 36. Phenotypic Analysis of Activation Antigens on Mitogenstimulated T Cells Utilizing Monoclonal Antibodies.- 37. T-Activation Antigens: Kinetics of Appearance and Effect on Cell Proliferation Studied with Monoclonal Antibodies.- VIII. Study of T Cell Leukemia-Associated Antigens.- 38. Antibody 3-40 Binds to Keratin and Vimentin Intermediate Filaments.- IX. Other Types of Studies and Description of New T Cell Markers.- 39. Screening of Monoclonal Antibodies against T Cell Differentiation Antigens Using Transfectants or Somatic Cell Hybrids.- 40. Association of IL-2 Production with the Expression of Dipeptidyl Peptidase IV (DPIV) on Human T Lymphocytes.- 41. A Novel Disulfide-Linked Cell Surface Molecule Present on Resting and Activated Human T Lymphocytes.- 42. T14, A Non-modulating 150-Kd T Cell Surface Antigen.- 43. Specific Membrane Lectin of Human T Suppressor Cells.
