Full Description
Esteemed researchers from different European laboratories provide state-of-the-art studies on biology and ageing, along with guidelines for future investigations. They cover such issues in molecular gerontological research as regulation of gene expression from DNA to RNA to functional proteins, origin of various age-associated diseases, genetic regulation of ageing and longevity, and different mechanisms of defense and repair. Other contributions evaluate new technologies, including transgenic organisms, and the use of nutritional and chemical modulators of ageing and lifespan.
Contents
1. Genetics of Ageing and Multifactorial Diseases.- 2. Ageing and Cancer: A Struggle of Tendencies.- 3. Maintaining the Stability of the Genome.- 4. Nuclear—Mitochondrial Interactions Involved in Biological Ageing.- 5. From Genes to Functional Gene Products during Ageing.- 6. Ageing of Cells in Vitro.- 7. Stress and Energy Metabolism in Age-Related Processes.- 8. Growth Factors and Ageing: The Case of Wound Healing.- 9. Immunosenescence: Paradoxes and New Perspectives Emerging from the Study of Healthy Centenarians.- 10. Drosophila as a Model System for Molecular Gerontology.- 11. Skin Ageing: The Relevance of Antioxidants.- 12. Cell Maintenance and Stress Response in Ageing and Longevity.- 13. From Molecular Gerontology to Healthy Old Age: Research Strategies.
